Access the full text.
Sign up today, get DeepDyve free for 14 days.
C. Bult, J. Eppig, J. Kadin, J. Richardson, J. Blake (2007)
The Mouse Genome Database (MGD): mouse biology and model systemsNucleic Acids Research, 36
R. Levitt, W. Mitzner (1989)
Autosomal recessive inheritance of airway hyperreactivity to 5-hydroxytryptamine.Journal of applied physiology, 67 3
L. Palmer, P. Burton, J. Faux, A. James, A. Musk, W. Cookson (2000)
Independent inheritance of serum immunoglobulin E concentrations and airway responsiveness.American journal of respiratory and critical care medicine, 161 6
M. Moffatt (2008)
Genes in asthma: new genes and new waysCurrent Opinion in Allergy and Clinical Immunology, 8
C. Karp, A. Grupe, E. Schadt, S. Ewart, Michelle Keane-Moore, P. Cuomo, J. Köhl, L. Wahl, D. Kuperman, S. Germer, D. Aud, G. Peltz, M. Wills-Karp (2000)
Identification of complement factor 5 as a susceptibility locus for experimental allergic asthmaNature Immunology, 1
A. Torkamanzehi, P. Boksa, Mouhssine Ayoubi, M. Fortier, N. Kin, E. Skamene, G. Rouleau, R. Joober (2006)
Identification of Informative Strains and Provisional QTL Mapping of Amphetamine (AMPH)-Induced Locomotion in Recombinant Congenic Strains (RCS) of MiceBehavior Genetics, 36
T. Wiltshire, M. Pletcher, S. Batalov, S. Barnes, L. Tarantino, M. Cooke, Hua Wu, Kevin Smylie, Andrey Santrosyan, N. Copeland, N. Jenkins, F. Kalush, R. Mural, R. Glynne, S. Kay, M. Adams, C. Fletcher, C. Fletcher (2003)
Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouseProceedings of the National Academy of Sciences of the United States of America, 100
T. Tran, A. Halayko (2007)
Extracellular matrix and airway smooth muscle interactions: a target for modulating airway wall remodelling and hyperresponsiveness?Canadian journal of physiology and pharmacology, 85 7
S. Thifault, Šeda Ondřej, Yulin Sun, A. Fortin, E. Skamene, Robert Lalonde, J. Tremblay, P. Hamet (2008)
Genetic determinants of emotionality and stress response in AcB/BcA recombinant congenic mice and in silico evidence of convergence with cardiovascular candidate genes.Human molecular genetics, 17 3
S. Daniels, S. Bhattacharrya, A. James, N. Leaves, Allan Young, M. Hill, J. Faux, Gerard Ryan, P. Souëf, G. Lathrop, A. Musk, W. Cookson, W. Cookson (1996)
A genome-wide search for quantitative trait loci underlying asthmaNature, 383
K. Gill, A. Boyle (2005)
Quantitative trait loci for novelty/stress-induced locomotor activation in recombinant inbred (RI) and recombinant congenic (RC) strains of miceBehavioural Brain Research, 161
K. Ackerman, Hailu Huang, H. Grasemann, C. Puma, J. Singer, Annie Hill, E. Lander, J. Nadeau, G. Churchill, J. Drazen, D. Beier (2005)
Interacting genetic loci cause airway hyperresponsiveness.Physiological genomics, 21 1
G. Zosky, P. Sly, P. Sly (2007)
Animal models of asthmaClinical & Experimental Allergy, 37
G. Sanctis, Mark Merchant, D. Beier, R. Dredge, J. Grobholz, T. Martin, E. Lander, J. Drazen (1995)
Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J miceNature Genetics, 11
Xin Xu, Z. Fang, Bin-yan Wang, Changzhong Chen, W. Guang, Yongtang Jin, Jianghua Yang, S. Lewitzky, A. Aelony, A. Parker, Joanne Meyer, S. Weiss, Xiping Xu (2001)
A genomewide search for quantitative-trait loci underlying asthma.American journal of human genetics, 69 6
Lyle Palmer, P. Rye, N. Gibson, P. Burton, Lou Landau, P. Lesouëf (2001)
Airway responsiveness in early infancy predicts asthma, lung function, and respiratory symptoms by school age.American journal of respiratory and critical care medicine, 163 1
D. Nicolae, N. Cox, L. Lester, Daniel Schneider, Z. Tan, C. Billstrand, S. Kuldanek, Joseph Donfack, P. Kogut, Nina Patel, J. Goodenbour, T. Howard, R. Wolf, G. Koppelman, S. White, R. Parry, D. Postma, D. Meyers, E. Bleecker, J. Hunt, J. Solway, C. Ober (2005)
Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21.American journal of human genetics, 76 2
Youming Zhang, J. Lefort, Virginia Kearsey, J. Silva, W. Cookson, B. Vargaftig (1999)
A genome-wide screen for asthma-associated quantitative trait loci in a mouse model of allergic asthma.Human molecular genetics, 8 4
J. McIntire, S. Umetsu, O. Akbari, M. Potter, V. Kuchroo, G. Barsh, G. Freeman, D. Umetsu, R. DeKruyff (2001)
Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene familyNature Immunology, 2
VP Krymskaya (2007)
Targeting the phosphatidylinositol 3-kinase pathway in airway smooth muscle: rationale and promiseBioDrugs, 21
Constance Smith, Jacqueline Finger, T. Hayamizu, I. McCright, J. Eppig, J. Kadin, J. Richardson, M. Ringwald (2006)
The mouse Gene Expression Database (GXD): 2007 updateNucleic Acids Research, 35
K. Huh, C. Fuhrer (2002)
Clustering of nicotinic acetylcholine receptors: From the neuromuscular junction to interneuronal synapsesMolecular Neurobiology, 25
D. Cockcroft, D. Killian, J. Mellon, F. Hargreave (1977)
Bronchial reactivity to inhaled histamine: a method and clinical surveyClinical & Experimental Allergy, 7
PM O’Byrne, MD Inman (2003)
Airway hyperresponsivenessChest, 123
R. Hopp, R. Townley, R. Biven, A. Bewtra, N. Nair (1990)
The presence of airway reactivity before the development of asthma.The American review of respiratory disease, 141 1
J. Bates, C. Irvin, V. Brusasco, J. Drazen, J. Fredberg, S. Loring, D. Eidelman, M. Ludwig, P. Macklem, James Martin, J. Milic‐Emili, Z. Hantos, R. Hyatt, S. Lai-Fook, Alan Leff, J. Solway, K. Lutchen, B. Suki, W. Mitzner, P. Paré, N. Pride, P. Sly (2004)
The use and misuse of Penh in animal models of lung disease.American journal of respiratory cell and molecular biology, 31 3
P. Eerdewegh, R. Little, J. Dupuis, R. Mastro, K. Falls, J. Simon, D. Torrey, Sunil Pandit, Joyce McKenny, K. Braunschweiger, A. Walsh, Ziying Liu, B. Hayward, C. Folz, S. Manning, A. Bawa, L. Saracino, Michelle Thackston, Y. Benchekroun, N. Capparell, Mei Wang, R. Adair, Yun Feng, J. Dubois, M. FitzGerald, Hui Huang, R. Gibson, K. Allen, A. Pedan, M. Danzig, S. Umland, R. Egan, F. Cuss, S. Rorke, J. Clough, J. Holloway, S. Holgate, T. Keith (2002)
Association of the ADAM33 gene with asthma and bronchial hyperresponsivenessNature, 418
G. Sanctis, Jonathan Singer, A. Jiao, C. Yandava, Y. Lee, T. Haynes, Eric Lander, D. Beier, J. Drazen (1999)
Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice.American journal of physiology. Lung cellular and molecular physiology, 277 6
M. Ringwald, J. Eppig, D. Begley, J. Corradi, I. McCright, T. Hayamizu, D. Hill, J. Kadin, J. Richardson (2001)
The Mouse Gene Expression Database (GXD)Nucleic acids research, 29 1
M. Wills-Karp, S. Ewart (2004)
Time to draw breath: asthma-susceptibility genes are identifiedNature Reviews Genetics, 5
B. Kest, S. Smith, A. Schorscher-Petcu, J. Austin, J. Ritchie, G. Klein, G. Rossi, A. Fortin, J. Mogil (2009)
Gnao1 (GαO protein) is a likely genetic contributor to variation in physical dependence on opioids in miceNeuroscience, 162
V. Carey, S. Weiss, I. Tager, S. Leeder, F. Speizer (1996)
Airways responsiveness, wheeze onset, and recurrent asthma episodes in young adolescents. The East Boston Childhood Respiratory Disease Cohort.American journal of respiratory and critical care medicine, 153 1
D. Vercelli (2008)
Discovering susceptibility genes for asthma and allergyNature Reviews Immunology, 8
WW Busse, RF Lemanske (2001)
AsthmaN Engl J Med, 344
C. Mihai, D. Iscru, L. Druhan, T. Elton, G. Agarwal (2006)
Discoidin domain receptor 2 inhibits fibrillogenesis of collagen type 1.Journal of molecular biology, 361 5
K. Gill, A. Boyle (2005)
Genetic analysis of alcohol intake in recombinant inbred and congenic strains derived from A/J and C57BL/6J progenitorsMammalian Genome, 16
B. Raby, E. Silverman, R. Lazarus, C. Lange, D. Kwiatkowski, S. Weiss (2003)
Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypes.Human molecular genetics, 12 16
A. Fortin, Eduardo Diez, D. Rochefort, L. Laroche, Danielle Malo, Danielle Malo, Guy Rouleau, Guy Rouleau, Philippe Gros, Philippe Gros, Emil Skamene, Emil Skamene (2001)
Recombinant congenic strains derived from A/J and C57BL/6J: a tool for genetic dissection of complex traits.Genomics, 74 1
D. Postma, E. Bleecker, P. Amelung, K. Holroyd, Jianfeng Xu, Carolien Panhuysen, D. Meyers, R. Levitt (1995)
Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy.The New England journal of medicine, 333 14
S. Ewart, D. Kuperman, E. Schadt, C. Tankersley, A. Grupe, D. Shubitowski, G. Peltz, M. Wills-Karp (2000)
Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice.American journal of respiratory cell and molecular biology, 23 4
K. Ganguly, T. Stoeger, S. Wesselkamper, C. Reinhard, M. Sartor, M. Medvedovic, C. Tomlinson, I. Bolle, J. Mason, G. Leikauf, H. Schulz (2007)
Candidate genes controlling pulmonary function in mice: transcript profiling and predicted protein structure.Physiological genomics, 31 3
M. Roy, Noémie Riendeau, J. Loredo-Osti, Danielle Malo (2006)
Complexity in the host response to Salmonella Typhimurium infection in AcB and BcA recombinant congenic strainsGenes and Immunity, 7
A. Fortin, L. Cardon, M. Tam, E. Skamene, M. Stevenson, P. Gros (2001)
Identification of a new malaria susceptibility locus (Char4) in recombinant congenic strains of miceProceedings of the National Academy of Sciences of the United States of America, 98
E. Neptune, P. Frischmeyer, D. Arking, Loretha Myers, T. Bunton, B. Gayraud, F. Ramirez, L. Sakai, H. Dietz (2003)
Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndromeNature Genetics, 33
S. Ewart, Wayne Mitzner, Deborah DiSilvestre, Deborah Meyers, Roy Levitt (1996)
Airway hyperresponsiveness to acetylcholine: segregation analysis and evidence for linkage to murine chromosome 6.American journal of respiratory cell and molecular biology, 14 5
Airway responsiveness is the ability of the airways to respond to bronchoconstricting stimuli by reducing their diameter. Airway hyperresponsiveness has been associated with asthma susceptibility in both humans and murine models, and it has been shown to be a complex and heritable trait. In particular, the A/J mouse strain is known to have hyperresponsive airways, while the C57BL/6 strain is known to be relatively refractory to bronchoconstricting stimuli. We analyzed recombinant congenic strains (RCS) of mice generated from these hyper- and hyporesponsive parental strains to identify genetic loci underlying the trait of airway responsiveness in response to methacholine as assessed by whole-body plethysmography. Our screen identified 16 chromosomal regions significantly associated with airway hyperresponsiveness (genome-wide P ≤ 0.05): 8 are supported by independent and previously published reports while 8 are entirely novel. Regions that overlap with previous reports include two regions on chromosome 2, three on chromosome 6, one on chromosome 15, and two on chromosome 17. The 8 novel regions are located on chromosome 1 (92–100 cM), chromosome 5 (>73 cM), chromosome 7 (>63 cM), chromosome 8 (52–67 cM), chromosome 10 (3–7 cM and >68 cM), and chromosome 12 (25–38 cM and >52 cM). Our data identify several likely candidate genes from the 16 regions, including Ddr2, Hc, Fbn1, Flt3, Utrn, Enpp2, and Tsc.
Mammalian Genome – Springer Journals
Published: Dec 15, 2009
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.