A quantitative trait locus (QTL) analysis was performed on the size and shape of the mandible in F2 mice between KK-A y and C57BL/6 J strains and the effect of the A y allele on the morphology of the mandible was analyzed. A total of 13 measurements were taken on each right mandible. By means of discriminant and canonical discriminant analyses, KK-A y males and KK males were exactly discriminated from each other. In contrast to its known effects on body weight, the A y allele reduced the overall size of the mandible. QTL analysis of the 13 measurements and on three principal components extracted from these measurements identified multiple QTLs. When F2 a/a and F2 A y /a were analyzed separately, 11 significant main-effect QTLs were identified in F2 a/a, whereas only two QTLs were identified in F2 A y /a. Although four significant interactions were identified, all were in F2 a/a. The A y allele thus made the difference in the size and shape of the mandible between strains obscure. Among mandible QTLs, those on Chrs 5 (Mssq6 and Mssq7) and 15 (Mssq14) were important. Mssq6 had an effect on the height of the posterior mandible. Mssq7 had an effect on mandible length. Mssq14 had an effect on the height of the anterior and posterior mandible. Mssq7 and Mssq14 also had an effect on the overall size. Thus, mandible QTLs have distinct and characteristic sites of action. Therefore, mandible morphology will be determined largely by the combination of these QTLs.
Mammalian Genome – Springer Journals
Published: Dec 6, 2008
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera