Identification of human homologues of the mouse mammary tumor virus receptor

Identification of human homologues of the mouse mammary tumor virus receptor Human breast tumors contain DNA sequences with high homology to the Mouse Mammary Tumor Virus (MMTV) env gene. env encodes the membrane glycoprotein that binds to the MMTV receptor (Mtvr) in mouse tissues and is required for infection. If humans become infected with MMTV, identification of a human Mtvr might shed light on the mechanism of infection. Here, we identified two human genes, Mtvr1 and Mtvr2, encoding proteins highly related to the mouse receptor. Mtvr-related sequences were also detected in other mammalian species. Thus, zoonotic transmission of MMTV is a real possibility given the existence of highly homologous MMTV receptors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Identification of human homologues of the mouse mammary tumor virus receptor

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Publisher
Springer-Verlag
Copyright
Copyright © 2002 by Springer-Verlag/Wien
Subject
Legacy
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s007050200007
Publisher site
See Article on Publisher Site

Abstract

Human breast tumors contain DNA sequences with high homology to the Mouse Mammary Tumor Virus (MMTV) env gene. env encodes the membrane glycoprotein that binds to the MMTV receptor (Mtvr) in mouse tissues and is required for infection. If humans become infected with MMTV, identification of a human Mtvr might shed light on the mechanism of infection. Here, we identified two human genes, Mtvr1 and Mtvr2, encoding proteins highly related to the mouse receptor. Mtvr-related sequences were also detected in other mammalian species. Thus, zoonotic transmission of MMTV is a real possibility given the existence of highly homologous MMTV receptors.

Journal

Archives of VirologySpringer Journals

Published: Mar 1, 2002

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