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I. Iourov, S. Vorsanova, T. Liehr, A. Kolotii, Y. Yurov (2009)
Increased chromosome instability dramatically disrupts neural genome integrity and mediates cerebellar degeneration in the ataxia-telangiectasia brain.Human molecular genetics, 18 14
I. Iourov, S. Vorsanova, Y. Yurov (2008)
Chromosomal mosaicism goes globalMolecular Cytogenetics, 1
Y. Yurov, I. Iourov, S. Vorsanova, T. Liehr, A. Kolotii, S. Kutsev, F. Pellestor, A. Beresheva, I. Demidova, V. Kravets, V. Monakhov, I. Soloviev (2007)
Aneuploidy and Confined Chromosomal Mosaicism in the Developing Human BrainPLoS ONE, 2
I. Iourov, S. Vorsanova, Y. Yurov (2006)
Intercellular Genomic (Chromosomal) Variations Resulting in Somatic Mosaicism: Mechanisms and ConsequencesCurrent Genomics, 7
I. Iourov, S. Vorsanova, Y. Yurov (2006)
Chromosomal variation in mammalian neuronal cells: known facts and attractive hypotheses.International review of cytology, 249
(2009)
Cytogenetic , Molecular Cytogenetic and Clinico Genealogical Investigation of Mothers Having Chil dren with Autism : A Search for Familial Genetic Mark ers of Autistic Disorders
S. Vorsanova, A. Kolotii, I. Iourov, V. Monakhov, E. Kirillova, I. Soloviev, Y. Yurov (2005)
Evidence for High Frequency of Chromosomal Mosaicism in Spontaneous Abortions Revealed by Interphase FISH AnalysisJournal of Histochemistry & Cytochemistry, 53
Y. Yurov, I. Iourov, V. Monakhov, I. Soloviev, V. Vostrikov, S. Vorsanova (2005)
The Variation of Aneuploidy Frequency in the Developing and Adult Human Brain Revealed by an Interphase FISH StudyJournal of Histochemistry & Cytochemistry, 53
J. Xia, C. Adams (2008)
252 – Leeds outcome stakeholders survey (loss)Schizophrenia Research, 98
Y. Yurov, V. Vostrikov, S. Vorsanova, V. Monakhov, I. Iourov (2001)
Multicolor fluorescent in situ hybridization on post-mortem brain in schizophrenia as an approach for identification of low-level chromosomal aneuploidy in neuropsychiatric diseasesBrain and Development, 23
I. Iourov, I. Soloviev, S. Vorsanova, V. Monakhov, Y. Yurov (2005)
An Approach for Quantitative Assessment of Fluorescence In Situ Hybridization (FISH) Signals for Applied Human Molecular CytogeneticsJournal of Histochemistry & Cytochemistry, 53
I. Iourov, S. Vorsanova, T. Liehr, Y. Yurov (2009)
Aneuploidy in the normal, Alzheimer's disease and ataxia-telangiectasia brain: Differential expression and pathological meaningNeurobiology of Disease, 34
(2009)
Cytogenetic, Molecular Cytogenetic and Clinico Genealogical Investigation of Mothers Having Chil dren with Autism: A Search for Familial Genetic Mark ers of Autistic Disorders, Zh
Y. Yurov, S. Vorsanova, I. Iourov, I. Demidova, A. Beresheva, V. Kravetz, V. Monakhov, A. Kolotii, V. Voinova-Ulas, N. Gorbachevskaya (2007)
Unexplained autism is frequently associated with low-level mosaic aneuploidyJournal of Medical Genetics, 44
S.G. Vorsanova, I.Yu. Yurov, I.V. Soloviev, Yu.B. Yurov (2008)
Geterokhromatinovye raiony khromosom cheloveka: kliniko-biologicheskie aspekty
Y. Yurov, I. Iourov, S. Vorsanova, I. Demidova, V. Kravetz, Alphia Beresheva, A. Kolotii, Viktor Monakchov, Natalia Uranova, V. Vostrikov, I. Soloviev, T. Liehr (2008)
The schizophrenia brain exhibits low-level aneuploidy involving chromosome 1Schizophrenia Research, 98
(2008)
Mosaic Aneuploidy in Ataxia Telangiectasia (Syn drome Lui–Bar) Brain Cells
I. Iourov, Thomas Liehr, S. Vorsanova, A. Kolotii, Y. Yurov (2006)
Visualization of interphase chromosomes in postmitotic cells of the human brain by multicolour banding (MCB)Chromosome Research, 14
Y. Yurov, S. Vorsanova, I. Iourov (2009)
GIN'n'CIN hypothesis of brain aging: deciphering the role of somatic genetic instabilities and neural aneuploidy during ontogenyMolecular Cytogenetics, 2
S. Vorsanova, I. Yurov, Demidova Ia, V. Voinova-Ulas, V. Kravets, I. Solov’ev, N. Gorbachevskaya, Y. Yurov (2007)
Variability in the heterochromatin regions of the chromosomes and chromosomal anomalies in children with autism: Identification of genetic markers of autistic spectrum disordersNeuroscience and Behavioral Physiology, 37
I. Iourov, S. Vorsanova, Y. Yurov (2008)
Molecular Cytogenetics and Cytogenomics of Brain DiseasesCurrent Genomics, 9
I. Iourov, T. Liehr, S. Vorsanova, Y. Yurov (2007)
Interphase chromosome-specific multicolor banding (ICS-MCB): a new tool for analysis of interphase chromosomes in their integrity.Biomolecular engineering, 24 4
Autism is one of the most widely spread mental diseases among children. Different genetic anomalies make a considerable contribution to the etiology of this disease; therefore, the identification of candidate genes of autism can be regarded as a topical task of modern medical genetics. The molecular cytogenetic examination of children with autism was carried out using high-resolution comparative genome hybridization and subsequent in silico analysis of chromosomal regions involved in unbalanced rearrangements. Five of 126 (4%) children with autism had unbalanced rearrangements of chromosomes 5, 17, 21 (deletions) and chromosomes 4 and 22 (duplications). The following candidate genes were identified in children with autism by in silico analysis: SCARB2, TPPP, PDCD6, SEPT5, GP1BB, PI4KA, NPTX1, STCH, NRIP1, and CXADR. These methods also allowed us to find a possible association between gene clusterization and the formation of the described chromosomal rearrangements. Thus, this study demonstrates that the molecular cytogenetic and bioinformatic methods can be successfully used to search for candidate genes of different diseases and analyze the genome organization.
Russian Journal of Genetics – Springer Journals
Published: Oct 13, 2010
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