Identification of a repressor of late gene expression within the AcMNPV genome

Identification of a repressor of late gene expression within the AcMNPV genome Viral replication and late gene expression of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) requires a series of late expression factors. We examined the AcMNPV genome for additional factors which affect late gene expression. During these investigations, a segment of the AcMNPV genome located immediately downstream to LEF-7 was found to possess a repressor activity. Elimination of this region resulted in greatly enhanced late gene expression. We were unable to link repressor activity to a single open reading frame, suggesting that a cis -acting element rather than a trans -acting factor is responsible for this phenomenon. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Identification of a repressor of late gene expression within the AcMNPV genome

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Publisher
Springer-Verlag
Copyright
Copyright © 2003 by Springer-Verlag/Wien
Subject
Legacy
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-003-0107-8
Publisher site
See Article on Publisher Site

Abstract

Viral replication and late gene expression of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) requires a series of late expression factors. We examined the AcMNPV genome for additional factors which affect late gene expression. During these investigations, a segment of the AcMNPV genome located immediately downstream to LEF-7 was found to possess a repressor activity. Elimination of this region resulted in greatly enhanced late gene expression. We were unable to link repressor activity to a single open reading frame, suggesting that a cis -acting element rather than a trans -acting factor is responsible for this phenomenon.

Journal

Archives of VirologySpringer Journals

Published: Jun 1, 2003

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