Mammalian Genome 12, 177–179 (2001). DOI: 10.1007/s003350010241 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2001 Identification, expression analysis, and mapping of B3galt6, a putative galactosyl transferase gene with similarity to Drosophila brainiac Susan E. Cole, Meredith S. Mao, Stuart H. Johnston,* Thomas F. Vogt** Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA Received: 31 May 2000 / Accepted: 19 September 2000 The identification of the vertebrate homologs of Drosophila genes BLAST analysis with this ORF indicated that, along with ho- involved in conserved intercellular signaling pathways has pro- mology to Drosophila brainiac, this protein had significant homol- vided rich resources for developmental studies. The Drosophila ogy to a family of b1,3 galactosyltransferases (Fig. 1). Identity brainiac (brn) gene was originally identified through screen for between the novel protein and the mammalian b1,3 galactosyl- sex-linked, female sterile genes (Gans et al. 1975). Mutations at transferases was 30%–34%, while identity with Drosophila brain- this locus cause the neurogenic phenotype for which it was named, iac was 31%. Sequence similarity ranged from 45% to 55% as well as fused dorsal appendages (reflecting dorsal/ventral pat- among the proteins. A conserved N-linked glycosylation site is terning defects in oocytes), abnormal
Mammalian Genome – Springer Journals
Published: Feb 1, 2001
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