Identification and characterization of the murine FK506 binding protein (FKBP) 12.6 gene

Identification and characterization of the murine FK506 binding protein (FKBP) 12.6 gene Mammalian Genome 9, 1069–1071 (1998). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1998 Identification and characterization of the murine FK506 binding protein (FKBP) 12.6 gene Jane A. Bennett, Yevette C. Clancy, John D. McNeish Pfizer Central Research, Groton, Connecticut 06340, USA Received: 15 May 1998 / Accepted: 12 August 1998 FK506 binding proteins (FKBP) are members of a family of pro- The published sequence of the hFKBP 12.6 (Lam et al. 1995) was teins called immunophilins. This highly conserved gene family has used to search a non-human expressed sequence tag (EST) data- been identified in prokaryotes, lower eukaryotes, plants, and mam- base. Initially, this search identified a murine EST that was similar mals. The immunophilins are members of the peptidylpropyl cis- to the human FKBP 12 gene. Further analysis determined that the trans isomerases (PPIases) enzyme family. PPIases catalyze the murine EST sequence was 91% identical to the reported hFKBP isomerization of peptide bonds on the amino side of proline resi- 12.6 cDNA sequence. An IMAGE clone (#390134) that contained dues from the naturally occurring trans configuration to a cis con- the entire insert was subcloned into pBluescript SK (Stratagene, figuration. This isomerization has been observed in approximately http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Identification and characterization of the murine FK506 binding protein (FKBP) 12.6 gene

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Publisher
Springer-Verlag
Copyright
Copyright © 1998 by Springer-Verlag New York Inc.
Subject
Life Sciences; Cell Biology; Animal Genetics and Genomics; Human Genetics
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003359900928
Publisher site
See Article on Publisher Site

Abstract

Mammalian Genome 9, 1069–1071 (1998). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1998 Identification and characterization of the murine FK506 binding protein (FKBP) 12.6 gene Jane A. Bennett, Yevette C. Clancy, John D. McNeish Pfizer Central Research, Groton, Connecticut 06340, USA Received: 15 May 1998 / Accepted: 12 August 1998 FK506 binding proteins (FKBP) are members of a family of pro- The published sequence of the hFKBP 12.6 (Lam et al. 1995) was teins called immunophilins. This highly conserved gene family has used to search a non-human expressed sequence tag (EST) data- been identified in prokaryotes, lower eukaryotes, plants, and mam- base. Initially, this search identified a murine EST that was similar mals. The immunophilins are members of the peptidylpropyl cis- to the human FKBP 12 gene. Further analysis determined that the trans isomerases (PPIases) enzyme family. PPIases catalyze the murine EST sequence was 91% identical to the reported hFKBP isomerization of peptide bonds on the amino side of proline resi- 12.6 cDNA sequence. An IMAGE clone (#390134) that contained dues from the naturally occurring trans configuration to a cis con- the entire insert was subcloned into pBluescript SK (Stratagene, figuration. This isomerization has been observed in approximately

Journal

Mammalian GenomeSpringer Journals

Published: Dec 1, 1998

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