Mammalian Genome 9, 1069–1071 (1998). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1998 Identification and characterization of the murine FK506 binding protein (FKBP) 12.6 gene Jane A. Bennett, Yevette C. Clancy, John D. McNeish Pfizer Central Research, Groton, Connecticut 06340, USA Received: 15 May 1998 / Accepted: 12 August 1998 FK506 binding proteins (FKBP) are members of a family of pro- The published sequence of the hFKBP 12.6 (Lam et al. 1995) was teins called immunophilins. This highly conserved gene family has used to search a non-human expressed sequence tag (EST) data- been identified in prokaryotes, lower eukaryotes, plants, and mam- base. Initially, this search identified a murine EST that was similar mals. The immunophilins are members of the peptidylpropyl cis- to the human FKBP 12 gene. Further analysis determined that the trans isomerases (PPIases) enzyme family. PPIases catalyze the murine EST sequence was 91% identical to the reported hFKBP isomerization of peptide bonds on the amino side of proline resi- 12.6 cDNA sequence. An IMAGE clone (#390134) that contained dues from the naturally occurring trans configuration to a cis con- the entire insert was subcloned into pBluescript SK (Stratagene, figuration. This isomerization has been observed in approximately
Mammalian Genome – Springer Journals
Published: Dec 1, 1998
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera