Access the full text.
Sign up today, get DeepDyve free for 14 days.
D. Blaas, E. Patzelt, E. Kuechler (1982)
Identification of the cap binding protein of influenza virus.Nucleic acids research, 10 15
(1991)
Influenza virus M 2 integral membrane protein is a homotetramer stabilized by formation of disulfide bond
A. Helenius (1992)
Unpacking the incoming influenza virusCell, 69
Kato Atsushi, Mizumoto Kiyohisa, Ishihama Akira (1985)
Purification and enzymatic properties of an RNA polymerase-RNA complex from influenza virus.Virus research, 3 2
A. Gregoriades, B. Frangione (1981)
Insertion of influenza M protein into the viral lipid bilayer and localization of site of insertionJournal of Virology, 40
B. Detjen, C. Angelo, M. Katze, R. Krug (1987)
The three influenza virus polymerase (P) proteins not associated with viral nucleocapsids in the infected cell are in the form of a complexJournal of Virology, 61
L. Holsinger, Robert Alams (1991)
Influenza virus M2 integral membrane protein is a homotetramer stabilized by formation of disulfide bonds.Virology, 183 1
P. Digard, V. Blok, S. Inglis (1989)
Complex formation between influenza virus polymerase proteins expressed in Xenopus oocytesVirology, 171
F. Baudin, C. Bach, S. Cusack, R. Ruigrok (1994)
Structure of influenza virus RNP. I. Influenza virus nucleoprotein melts secondary structure in panhandle RNA and exposes the bases to the solvent.The EMBO Journal, 13
P. Fortes, A. Beloso, Juan Ortín (1994)
Influenza virus NS1 protein inhibits pre‐mRNA splicing and blocks mRNA nucleocytoplasmic transport.The EMBO Journal, 13
A. Zvonarjev, Y. Ghendon (1980)
Influence of membrane (M) protein on influenza A virus virion transcriptase activity in vitro and its susceptibility to rimantadineJournal of Virology, 33
K. Yamanaka, Akira Ishihama, Kyosuke Nagata (1990)
Reconstitution of influenza virus RNA-nucleoprotein complexes structurally resembling native viral ribonucleoprotein cores.The Journal of biological chemistry, 265 19
M. Baez, P. Palese, E. Kilbourne (1980)
Gene composition of high-yielding influenza vaccine strains obtained by recombination.The Journal of infectious diseases, 141 3
Yuan Lu, X. Qian, R. Krug (1994)
The influenza virus NS1 protein: a novel inhibitor of pre-mRNA splicing.Genes & development, 8 15
I. Ulmanen, B. Broni, R. Krug (1981)
Role of two of the influenza virus core P proteins in recognizing cap 1 structures (m7GpppNm) on RNAs and in initiating viral RNA transcription.Proceedings of the National Academy of Sciences of the United States of America, 78 12
K. Enami, Takeshi Sato, S. Nakada, Masayoshi, Enami (1994)
Influenza virus NS1 protein stimulates translation of the M1 proteinJournal of Virology, 68
A. Klimov, N. Sokolov, N. Orlova, V. Ginzburg (1991)
Correlation of amino acid residues in the M1 and M2 proteins of influenza virus with high yielding properties.Virus research, 19 1
G. Shapiro, R. Krug (1988)
Influenza virus RNA replication in vitro: synthesis of viral template RNAs and virion RNAs in the absence of an added primerJournal of Virology, 62
J. Robertson, C. Nicolson, D. Major, Edwin Robertson, J. Wood (1993)
The role of amniotic passage in the egg-adaptation of human influenza virus is revealed by haemagglutinin sequence analyses.The Journal of general virology, 74 ( Pt 10)
(1985)
Mutations in X - 37 influenza virus vaccine strain 377 material and comparison with the HA of laboratory - derived virus
M. Pons, I. Schulze, G. Hirst, R. Hauser (1969)
Isolation and characterization of the ribonucleoprotein of influenza virus.Virology, 39 2
A. Klimov, Y. Ghendon, H. Závadová, J. Brouček, T. Medvedeva (1983)
High reproduction capacity of recombinants between H3N2 human influenza and fowl plague viruses is due to the gene coding for M proteins.Acta virologica, 27 5
E. Rocha, Xiyan Xu, H. Hall, James Allen, H. Regnery, Nancy Cox (1993)
Comparison of 10 influenza A (H1N1 and H3N2) haemagglutinin sequences obtained directly from clinical specimens to those of MDCK cell- and egg-grown viruses.The Journal of general virology, 74 ( Pt 11)
Z. Ye, R. Pal, J. Fox, R. Wagner (1987)
Functional and antigenic domains of the matrix (M1) protein of influenza A virusJournal of Virology, 61
Masahira Hattori, Y. Sakaki (1986)
Dideoxy sequencing method using denatured plasmid templates.Analytical biochemistry, 152 2
L. Pinto, L. Holsinger, R. Lamb (1992)
Influenza virus M2 protein has ion channel activityCell, 69
Yuan Lu, M. Wambach, M. Katze, R. Krug (1995)
Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor.Virology, 214 1
Ann Beaton, Robert Krug (1986)
Transcription antitermination during influenza viral template RNA synthesis requires the nucleocapsid protein and the absence of a 5' capped end.Proceedings of the National Academy of Sciences of the United States of America, 83 17
R. Ruigrok, L. Calder, S. Wharton (1989)
Electron microscopy of the influenza virus submembranal structure.Virology, 173 1
Y. Qiu, R. Krug (1994)
The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A)Journal of Virology, 68
J. Braam, I. Ulmanen, R. Krug (1983)
Molecular model of a eucaryotic transcription complex: Functions and movements of influenza P proteins during capped RNA-primed transcriptionCell, 34
S. Luna, P. Fortes, A. Beloso, Juan Ortín (1995)
Influenza virus NS1 protein enhances the rate of translation initiation of viral mRNAsJournal of Virology, 69
R. O'neill, J. Talon, P. Palese (1998)
The influenza virus NEP (NS2 protein) mediates the nuclear export of viral ribonucleoproteinsThe EMBO Journal, 17
X-31(H3N2) virus, which is a high yielding reassortant between A/PR/8/34(H1N1) and A/Aichi/68(H3N2), is currently used as a backbone strain for influenza vaccine production. The sequence of the current X-31 virus was determined from cloned cDNA of 6 internal RNA genes, and was compared with the original sequence of the A/PR/8/34 virus. 71 point mutations were accumulated in the six internal viral genes (PB2, PB1, PA, NP, M and NS). These nucleotide changes encode 23 amino acid substitutions in seven viral proteins (PB2, PB1, PA, M1, M2, NS1 and NS2). Among three polymerase genes, a significantly low mutation frequency was observed in PA gene as compared to PB2 and PB1. The mutation frequency at the nucleotide level was significantly low in NP gene without any amino acid substitution, being only about 20% of those observed in 5 other internal genes. The unequal distribution of mutations among different viral proteins may correlate with individual role of each protein in viral growth.
Archives of Virology – Springer Journals
Published: Mar 1, 2001
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.