Reactions 1680, p162 - 2 Dec 2017 Mild fatigue, easy bruising and atrial fibrillation: 2 case reports In a case series, two patients were described, out of whom a 73-year-old woman developed mild fatigue and easy bruising and a 77-year-old man developed atrial fibrillation during treatment with ibrutinib [route, time to reactions onsets and outcomes not stated]. Patient 1: A 73-year-old woman, who had a history of B-cell prolymphocytic leukaemia, was started on ibrutinib 420mg daily. She had also received rituximab and enoxaparin. Her treatment course with ibrutinib was complicated by mild fatigue and easy bruising. The treatment with ibrutinib was maintained. She remained on ibrutinib for 15 months. Patient 2: A 77-year-old man, who had a history of B-cell prolymphocytic leukaemia, was started on ibrutinib 420 mg/day. His relevant medical history included coronary artery disease and hypertension. He had also received unspecified antibiotics and steroids, bendamustine and rituximab. His treatment course with ibrutinib was complicated by an episode of atrial fibrillation, which required a brief discontinuation of ibrutinib therapy. Later, ibrutinib was restarted and his constitutional symptoms resolved with therapy. He remained on ibrutinib for 12 months. Author comment: "Therapy was complicated by mild fatigue and easy bruising, not requiring either dose adjustment or interruption." "The treatment course was complicated by an episode of atrial fibrillation which required a brief interruption of ibrutinib therapy." Gordon MJ, et al. Ibrutinib is an effective treatment for B-cell prolymphocytic leukaemia. British Journal of Haematology 179: 501-503, No. 3, Nov 2017. Available from: URL: http://doi.org/10.1111/bjh.14224 - USA 803284481 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680
Reactions Weekly – Springer Journals
Published: Dec 2, 2017
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