Hypoparathyroidism is a relatively rare endocrine disease characterised by either null or inappropriately low secretion of parathyroid hormone (PTH) for serum calcium levels. The other main laboratory findings include hypocalcaemia, inappropri- ately normal or high urine calcium excretion and hyperphosphataemia with low urine phosphate excretion. The management of hypoparathyroidism should be tailored to each individual case, which makes it a demanding undertaking in everyday clinical practice. In this review, we sought to focus on the diagnostic approach of hypoparathyroidism and the therapeutic challenges of the disease from a clinical perspective. Conventional treatment with vitamin D analogues and calcium salts is no longer the only available treatment, since replacement treatment with PTH(1-84) has recently been approved for the disease. However, the optimal treatment schedule is yet to be defined. . . . Keywords Hypoparathyroidism Calcium PTH1-34 PTH1-84 Introduction focus on the therapeutic challenges of the disease from a clinical perspective. Given the recent advances in the replacement treat- Calcium homeostasis is mainly regulated by parathyroid hor- ment of the disease, conventional treatment with vitamin D mone (PTH), while calcitriol, the active form of vitamin D, analogues and calcium salts is no longer the only available and to a considerably lesser
Hormones – Springer Journals
Published: Jun 6, 2018
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