Psychopharmacology (2017) 234:2761–2776 DOI 10.1007/s00213-017-4673-y ORIGINAL INVESTIGATION Hypocretin receptor 1 blockade produces bimodal modulation of cocaine-associated mesolimbic dopamine signaling 1 1 1 2 2 1 K. A. Levy & Z. D. Brodnik & J. K. Shaw & D. A. Perrey & Y. Zhang & R. A. España Received: 30 March 2017 /Accepted: 6 June 2017 /Published online: 30 June 2017 Springer-Verlag GmbH Germany 2017 Abstract attenuated cocaine-induced dopamine uptake inhibition at Rationale Cocaine addiction is a chronic psychiatric disorder the level of dopamine terminals. characterized by pathological motivation to obtain cocaine and Conclusion Our results provide support for the standing hy- behavioral and neurochemical hypersensitivity to cocaine- pothesis that HCRTr1 blockade suppresses endogenous phasic associated cues. These features of cocaine addiction are thought dopamine signals, likely via actions at dopamine cell bodies. to be driven by aberrant phasic dopamine signaling. We previ- These results also elucidate a second process through which ously demonstrated that blockade of the hypocretin receptor 1 HCRTr1 blockade attenuates the effects of cocaine by reduc- (HCRTr1) attenuates cocaine self-administration and reduces ing cocaine sensitivity at dopamine terminals. cocaine-induced enhancement of dopamine signaling. Despite . . this evidence, the effects of HCRTr1 blockade on endogenous Keywords
Psychopharmacology – Springer Journals
Published: Jun 30, 2017
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