Hypocretin receptor 1 blockade produces bimodal modulation of cocaine-associated mesolimbic dopamine signaling

Hypocretin receptor 1 blockade produces bimodal modulation of cocaine-associated mesolimbic... Psychopharmacology (2017) 234:2761–2776 DOI 10.1007/s00213-017-4673-y ORIGINAL INVESTIGATION Hypocretin receptor 1 blockade produces bimodal modulation of cocaine-associated mesolimbic dopamine signaling 1 1 1 2 2 1 K. A. Levy & Z. D. Brodnik & J. K. Shaw & D. A. Perrey & Y. Zhang & R. A. España Received: 30 March 2017 /Accepted: 6 June 2017 /Published online: 30 June 2017 Springer-Verlag GmbH Germany 2017 Abstract attenuated cocaine-induced dopamine uptake inhibition at Rationale Cocaine addiction is a chronic psychiatric disorder the level of dopamine terminals. characterized by pathological motivation to obtain cocaine and Conclusion Our results provide support for the standing hy- behavioral and neurochemical hypersensitivity to cocaine- pothesis that HCRTr1 blockade suppresses endogenous phasic associated cues. These features of cocaine addiction are thought dopamine signals, likely via actions at dopamine cell bodies. to be driven by aberrant phasic dopamine signaling. We previ- These results also elucidate a second process through which ously demonstrated that blockade of the hypocretin receptor 1 HCRTr1 blockade attenuates the effects of cocaine by reduc- (HCRTr1) attenuates cocaine self-administration and reduces ing cocaine sensitivity at dopamine terminals. cocaine-induced enhancement of dopamine signaling. Despite . . this evidence, the effects of HCRTr1 blockade on endogenous Keywords http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Hypocretin receptor 1 blockade produces bimodal modulation of cocaine-associated mesolimbic dopamine signaling

Loading next page...
 
/lp/springer_journal/hypocretin-receptor-1-blockade-produces-bimodal-modulation-of-cocaine-hW16vJzC4r
Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany
Subject
Biomedicine; Neurosciences; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
D.O.I.
10.1007/s00213-017-4673-y
Publisher site
See Article on Publisher Site

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial