Hyperoxaluria in a Model of Mini-Gastric Bypass Surgery in Rats

Hyperoxaluria in a Model of Mini-Gastric Bypass Surgery in Rats OBES SURG (2017) 27:3202–3208 DOI 10.1007/s11695-017-2725-3 ORIGINAL CONTRIBUTIONS 1 1 1 1 Milene S. Ormanji & Fernando Korkes & Renata Meca & Crysthiane S.R.A. Ishiy & 1 1 1 Gustavo H.C. Finotti & Renato R.N. Ferraz & Ita P. Heilberg Published online: 26 May 2017 Springer Science+Business Media New York 2017 Abstract fat and oxalate (Fat + Ox), final values of urinary oxalate and Background Bariatric surgery is associated with calcium oxalate supersaturation risk were markedly and sig- hyperoxaluria hence predisposing to nephrolithiasis. The pres- nificantly increased versus baseline or Sham animals under ent study aimed to investigate the underlying mechanisms the same diet, as well as MGB groups under other diets. contributing to increased urinary oxalate in a mini-gastric by- Slc26a3 was decreased in biliopancreatic limbs of MGB rats, pass (MGB) surgery model in rats under different dietary con- probably reflecting a physiological adaptation to the restric- ditions. The expression of intestinal oxalate transporters was tion of food passage. Slc26a6 was not altered in any harvested also evaluated. intestinal fragment. Methods Male rats underwent MGB (n = 21) or Sham proce- Conclusions A high-fat and oxalate diet induced dure (n = 21) and after recovery were fed a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Obesity Surgery Springer Journals

Hyperoxaluria in a Model of Mini-Gastric Bypass Surgery in Rats

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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer Science+Business Media New York
Subject
Medicine & Public Health; Surgery
ISSN
0960-8923
eISSN
1708-0428
D.O.I.
10.1007/s11695-017-2725-3
Publisher site
See Article on Publisher Site

Abstract

OBES SURG (2017) 27:3202–3208 DOI 10.1007/s11695-017-2725-3 ORIGINAL CONTRIBUTIONS 1 1 1 1 Milene S. Ormanji & Fernando Korkes & Renata Meca & Crysthiane S.R.A. Ishiy & 1 1 1 Gustavo H.C. Finotti & Renato R.N. Ferraz & Ita P. Heilberg Published online: 26 May 2017 Springer Science+Business Media New York 2017 Abstract fat and oxalate (Fat + Ox), final values of urinary oxalate and Background Bariatric surgery is associated with calcium oxalate supersaturation risk were markedly and sig- hyperoxaluria hence predisposing to nephrolithiasis. The pres- nificantly increased versus baseline or Sham animals under ent study aimed to investigate the underlying mechanisms the same diet, as well as MGB groups under other diets. contributing to increased urinary oxalate in a mini-gastric by- Slc26a3 was decreased in biliopancreatic limbs of MGB rats, pass (MGB) surgery model in rats under different dietary con- probably reflecting a physiological adaptation to the restric- ditions. The expression of intestinal oxalate transporters was tion of food passage. Slc26a6 was not altered in any harvested also evaluated. intestinal fragment. Methods Male rats underwent MGB (n = 21) or Sham proce- Conclusions A high-fat and oxalate diet induced dure (n = 21) and after recovery were fed a

Journal

Obesity SurgerySpringer Journals

Published: May 26, 2017

References

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