Hypericum perforatum Modulates Apoptosis and Calcium Mobilization Through Voltage-Gated and TRPM2 Calcium Channels in Neutrophil of Patients with Behcet’s Disease

Hypericum perforatum Modulates Apoptosis and Calcium Mobilization Through Voltage-Gated and TRPM2... J Membrane Biol (2014) 247:253–262 DOI 10.1007/s00232-014-9630-7 Hypericum perforatum Modulates Apoptosis and Calcium Mobilization Through Voltage-Gated and TRPM2 Calcium Channels in Neutrophil of Patients with Behcet’s Disease • • Mustafa Nazırog ˘ lu Mehmet S ¸ ahin • • • Bilal C ¸ig ˘ Mehmet Aykur Ijlal Erturan Yunus Ugan Received: 7 August 2013 / Accepted: 6 January 2014 / Published online: 23 January 2014 Springer Science+Business Media New York 2014 2? Abstract Behcet’s disease (BD) is a chronic, inflammatory, neutrophils were stimulated by fMLP as a Ca -concentration and multisystemic condition although its pathogenesis is agonist and oxidative stress former. Caspase-3, caspase-9, 2? uncertain. Main component of St. John’s wort (Hypericum apoptosis, lipid peroxidation, and [Ca ] values were high in perforatum, HP) is hyperforin and induces antiinflammatory the patient groups, although cell viability, glutathione (GSH), and antioxidant properties. We aimed to investigate effects of and glutathione peroxidase (GSH-Px) values were low in 2? 2? HP on oxidative stress, apoptosis, and cytosolic-free Ca patient group. However, the [Ca ] , caspase-3, and caspase-9 2? [Ca ] concentration in neutrophil of BD patients. Nine new- values decreased markedly in patient?HP group although 2? diagnosed active patients with BD and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Hypericum perforatum Modulates Apoptosis and Calcium Mobilization Through Voltage-Gated and TRPM2 Calcium Channels in Neutrophil of Patients with Behcet’s Disease

Loading next page...
 
/lp/springer_journal/hypericum-perforatum-modulates-apoptosis-and-calcium-mobilization-zW2N70B1Tn
Publisher
Springer US
Copyright
Copyright © 2014 by Springer Science+Business Media New York
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s00232-014-9630-7
Publisher site
See Article on Publisher Site

Abstract

J Membrane Biol (2014) 247:253–262 DOI 10.1007/s00232-014-9630-7 Hypericum perforatum Modulates Apoptosis and Calcium Mobilization Through Voltage-Gated and TRPM2 Calcium Channels in Neutrophil of Patients with Behcet’s Disease • • Mustafa Nazırog ˘ lu Mehmet S ¸ ahin • • • Bilal C ¸ig ˘ Mehmet Aykur Ijlal Erturan Yunus Ugan Received: 7 August 2013 / Accepted: 6 January 2014 / Published online: 23 January 2014 Springer Science+Business Media New York 2014 2? Abstract Behcet’s disease (BD) is a chronic, inflammatory, neutrophils were stimulated by fMLP as a Ca -concentration and multisystemic condition although its pathogenesis is agonist and oxidative stress former. Caspase-3, caspase-9, 2? uncertain. Main component of St. John’s wort (Hypericum apoptosis, lipid peroxidation, and [Ca ] values were high in perforatum, HP) is hyperforin and induces antiinflammatory the patient groups, although cell viability, glutathione (GSH), and antioxidant properties. We aimed to investigate effects of and glutathione peroxidase (GSH-Px) values were low in 2? 2? HP on oxidative stress, apoptosis, and cytosolic-free Ca patient group. However, the [Ca ] , caspase-3, and caspase-9 2? [Ca ] concentration in neutrophil of BD patients. Nine new- values decreased markedly in patient?HP group although 2? diagnosed active patients with BD and

Journal

The Journal of Membrane BiologySpringer Journals

Published: Jan 23, 2014

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off