Hypericum perforatum Modulates Apoptosis and Calcium Mobilization Through Voltage-Gated and TRPM2 Calcium Channels in Neutrophil of Patients with Behcet’s Disease

Hypericum perforatum Modulates Apoptosis and Calcium Mobilization Through Voltage-Gated and TRPM2... J Membrane Biol (2014) 247:253–262 DOI 10.1007/s00232-014-9630-7 Hypericum perforatum Modulates Apoptosis and Calcium Mobilization Through Voltage-Gated and TRPM2 Calcium Channels in Neutrophil of Patients with Behcet’s Disease • • Mustafa Nazırog ˘ lu Mehmet S ¸ ahin • • • Bilal C ¸ig ˘ Mehmet Aykur Ijlal Erturan Yunus Ugan Received: 7 August 2013 / Accepted: 6 January 2014 / Published online: 23 January 2014 Springer Science+Business Media New York 2014 2? Abstract Behcet’s disease (BD) is a chronic, inflammatory, neutrophils were stimulated by fMLP as a Ca -concentration and multisystemic condition although its pathogenesis is agonist and oxidative stress former. Caspase-3, caspase-9, 2? uncertain. Main component of St. John’s wort (Hypericum apoptosis, lipid peroxidation, and [Ca ] values were high in perforatum, HP) is hyperforin and induces antiinflammatory the patient groups, although cell viability, glutathione (GSH), and antioxidant properties. We aimed to investigate effects of and glutathione peroxidase (GSH-Px) values were low in 2? 2? HP on oxidative stress, apoptosis, and cytosolic-free Ca patient group. However, the [Ca ] , caspase-3, and caspase-9 2? [Ca ] concentration in neutrophil of BD patients. Nine new- values decreased markedly in patient?HP group although 2? diagnosed active patients with BD and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Hypericum perforatum Modulates Apoptosis and Calcium Mobilization Through Voltage-Gated and TRPM2 Calcium Channels in Neutrophil of Patients with Behcet’s Disease

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Publisher
Springer US
Copyright
Copyright © 2014 by Springer Science+Business Media New York
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s00232-014-9630-7
Publisher site
See Article on Publisher Site

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