Purpose of Review Our aim was to discuss the hygiene hy- conditions can be responsible for the rise in the incidences of pothesis and current thinking about it. allergic disease and asthma. Protective effect of food-borne mi- Recent Findings Hygiene hypothesis suggests that an under- crobes on allergic diseases is another remarkable issue. lying reason for the recent prominent rise in allergic diseases . . may be linked with the diminution of the incidence of early Keywords Hygiene hypothesis Atopic disorders Microbial . . . childhood infections, which can be transmitted by means of exposure Sanitation Antibiotics Urban living contact with older siblings. Hygiene hypothesis suggests that contact with microbes in the environment in early life through pets, unpasteurized food, and nonsterilized water may protect Introduction from atopic diseases. Exposure to microbial pathogens and animals in infancy prevents atopy by Th -like cytokine re- 1 While infectious disease and hygiene have been key public sponses or by modifying Th -like immune responses. 2 health issues for centuries , allergic diseases have only rel- Chronic infection and inflammation may protect against atop- atively recently been regarded as a significant health burden. ic disease. Alteration of exposure to microorganisms and ac-
Current Otorhinolaryngology Reports – Springer Journals
Published: Jul 27, 2017
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