Hydroxychloroquine

Hydroxychloroquine Reactions 1680, p161 - 2 Dec 2017 Retinal toxicity: 17 case reports In a retrospective study, 17 patients (16 women and one man, aged 34 77 years) were described, who developed retinal toxicity during treatment with hydroxychloroquine [routes, time to reactions onsets and outcomes not stated]. Eight of the 17 patients were diagnosed with systemic lupus erythematosus and the rest were diagnosed with rheumatoid arthritis. All the patients received treatment with hydroxychloroquine at a daily dosage ranged from – – 4.9 9.1 mg/kg for the total duration of 6.7 21.9 years. However, following hydroxychloroquine administration, the visual field testing showed findings that varied from partial or complete ring scotoma sparing central fovea to subtle defects on the pattern deviation plot. The spectral domain optical coherence tomography (SD-OCT) showed thinning of outer nuclear layer or disruption of perifoveal photoreceptor inner segment/outer segment junction. The fundus autofluorescence (FAF) imaging revealed photoreceptor damage (except in one patient) as hyperautofluorescence by accumulated lipofuscin or hypoautofluorescence due to retinal pigment epithelial cell loss. These ophthalmological findings led to the diagnosis of early, moderate or severe retinal toxicity, which was considered to be related with hydroxychloroquine administration. The pattern of the retinal toxicity varied from parafoveal or pericentral to mixed. Author comment: "[Hydroxychloroquine] retinal toxicity is associated with duration of [hydroxychloroquine] use, daily [hydroxychloroquine] dose, and presence of kidney disease." "We found 17 patients (13.8%) with [Hydroxychloroquine] retinal toxicity among 123 patients." Kim J-W, et al. Risk of retinal toxicity in longterm users of hydroxychloroquine. The Journal of Rheumatology 44: 1674-1679, No. 11, Nov 2017. Available from: URL: http://doi.org/10.3899/jrheum.170158 - South Korea 803285479 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Hydroxychloroquine

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
Free
1 page

Loading next page...
1 Page
 
/lp/springer_journal/hydroxychloroquine-8n6jE1zwjR
Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-39092-2
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p161 - 2 Dec 2017 Retinal toxicity: 17 case reports In a retrospective study, 17 patients (16 women and one man, aged 34 77 years) were described, who developed retinal toxicity during treatment with hydroxychloroquine [routes, time to reactions onsets and outcomes not stated]. Eight of the 17 patients were diagnosed with systemic lupus erythematosus and the rest were diagnosed with rheumatoid arthritis. All the patients received treatment with hydroxychloroquine at a daily dosage ranged from – – 4.9 9.1 mg/kg for the total duration of 6.7 21.9 years. However, following hydroxychloroquine administration, the visual field testing showed findings that varied from partial or complete ring scotoma sparing central fovea to subtle defects on the pattern deviation plot. The spectral domain optical coherence tomography (SD-OCT) showed thinning of outer nuclear layer or disruption of perifoveal photoreceptor inner segment/outer segment junction. The fundus autofluorescence (FAF) imaging revealed photoreceptor damage (except in one patient) as hyperautofluorescence by accumulated lipofuscin or hypoautofluorescence due to retinal pigment epithelial cell loss. These ophthalmological findings led to the diagnosis of early, moderate or severe retinal toxicity, which was considered to be related with hydroxychloroquine administration. The pattern of the retinal toxicity varied from parafoveal or pericentral to mixed. Author comment: "[Hydroxychloroquine] retinal toxicity is associated with duration of [hydroxychloroquine] use, daily [hydroxychloroquine] dose, and presence of kidney disease." "We found 17 patients (13.8%) with [Hydroxychloroquine] retinal toxicity among 123 patients." Kim J-W, et al. Risk of retinal toxicity in longterm users of hydroxychloroquine. The Journal of Rheumatology 44: 1674-1679, No. 11, Nov 2017. Available from: URL: http://doi.org/10.3899/jrheum.170158 - South Korea 803285479 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off