Hydrotrope promoted in situ azidonation followed by copper catalyzed regioselective synthesis of β-hydroxytriazoles

Hydrotrope promoted in situ azidonation followed by copper catalyzed regioselective synthesis of... Keywords Hydrotrope  b-Hydroxytriazoles  One-pot synthesis  Click chemistry & Rajashri Salunkhe rsschem1@gmail.com Department of Chemistry, Shivaji University, Kolhapur, MS 416004, India 123 4176 A. Patil, R. Salunkhe Introduction The principles of green chemistry include the designing and implementation of novel sustainable methodologies which have minimal impact on the environment. Owing to this, the areas of research have been defined by the scientific community and a myriad of efforts has been undertaken for the same [1–4]. One of such approach is to use water as a reaction medium. The barrier of solubilization of organic reactants in aqueous medium is overcome by using green additives like hydrotropes; which increases the water solubility dramatically up to 200-fold. Hydrotropes are short chain amphiphiles structurally resembling surfactants but the mode of action is based on critical aggregation concentration (cac) of hydrotrope [5–7]. The salient structural characteristic of hydrotropes includes an anionic group and hydrophobic aromatic ring. The amphiphilic molecular structure of the hydrotrope dramatically increases the solubility of sparingly soluble organic molecules in water. Hydrotropic solutions precipitate the solute on dilution with water, which permits the recovery of the hydrotropic solution for re-use. Azides are the important intermediates in organic chemistry [8, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Hydrotrope promoted in situ azidonation followed by copper catalyzed regioselective synthesis of β-hydroxytriazoles

Loading next page...
Springer Netherlands
Copyright © 2017 by Springer Science+Business Media Dordrecht
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial