Keywords Hydrotrope b-Hydroxytriazoles One-pot synthesis Click chemistry & Rajashri Salunkhe firstname.lastname@example.org Department of Chemistry, Shivaji University, Kolhapur, MS 416004, India 123 4176 A. Patil, R. Salunkhe Introduction The principles of green chemistry include the designing and implementation of novel sustainable methodologies which have minimal impact on the environment. Owing to this, the areas of research have been deﬁned by the scientiﬁc community and a myriad of efforts has been undertaken for the same [1–4]. One of such approach is to use water as a reaction medium. The barrier of solubilization of organic reactants in aqueous medium is overcome by using green additives like hydrotropes; which increases the water solubility dramatically up to 200-fold. Hydrotropes are short chain amphiphiles structurally resembling surfactants but the mode of action is based on critical aggregation concentration (cac) of hydrotrope [5–7]. The salient structural characteristic of hydrotropes includes an anionic group and hydrophobic aromatic ring. The amphiphilic molecular structure of the hydrotrope dramatically increases the solubility of sparingly soluble organic molecules in water. Hydrotropic solutions precipitate the solute on dilution with water, which permits the recovery of the hydrotropic solution for re-use. Azides are the important intermediates in organic chemistry [8,
Research on Chemical Intermediates – Springer Journals
Published: Jan 31, 2017
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