Hydrotrope promoted in situ azidonation followed by copper catalyzed regioselective synthesis of β-hydroxytriazoles

Hydrotrope promoted in situ azidonation followed by copper catalyzed regioselective synthesis of... Keywords Hydrotrope  b-Hydroxytriazoles  One-pot synthesis  Click chemistry & Rajashri Salunkhe rsschem1@gmail.com Department of Chemistry, Shivaji University, Kolhapur, MS 416004, India 123 4176 A. Patil, R. Salunkhe Introduction The principles of green chemistry include the designing and implementation of novel sustainable methodologies which have minimal impact on the environment. Owing to this, the areas of research have been defined by the scientific community and a myriad of efforts has been undertaken for the same [1–4]. One of such approach is to use water as a reaction medium. The barrier of solubilization of organic reactants in aqueous medium is overcome by using green additives like hydrotropes; which increases the water solubility dramatically up to 200-fold. Hydrotropes are short chain amphiphiles structurally resembling surfactants but the mode of action is based on critical aggregation concentration (cac) of hydrotrope [5–7]. The salient structural characteristic of hydrotropes includes an anionic group and hydrophobic aromatic ring. The amphiphilic molecular structure of the hydrotrope dramatically increases the solubility of sparingly soluble organic molecules in water. Hydrotropic solutions precipitate the solute on dilution with water, which permits the recovery of the hydrotropic solution for re-use. Azides are the important intermediates in organic chemistry [8, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Hydrotrope promoted in situ azidonation followed by copper catalyzed regioselective synthesis of β-hydroxytriazoles

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Publisher
Springer Netherlands
Copyright
Copyright © 2017 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-017-2871-1
Publisher site
See Article on Publisher Site

Abstract

Keywords Hydrotrope  b-Hydroxytriazoles  One-pot synthesis  Click chemistry & Rajashri Salunkhe rsschem1@gmail.com Department of Chemistry, Shivaji University, Kolhapur, MS 416004, India 123 4176 A. Patil, R. Salunkhe Introduction The principles of green chemistry include the designing and implementation of novel sustainable methodologies which have minimal impact on the environment. Owing to this, the areas of research have been defined by the scientific community and a myriad of efforts has been undertaken for the same [1–4]. One of such approach is to use water as a reaction medium. The barrier of solubilization of organic reactants in aqueous medium is overcome by using green additives like hydrotropes; which increases the water solubility dramatically up to 200-fold. Hydrotropes are short chain amphiphiles structurally resembling surfactants but the mode of action is based on critical aggregation concentration (cac) of hydrotrope [5–7]. The salient structural characteristic of hydrotropes includes an anionic group and hydrophobic aromatic ring. The amphiphilic molecular structure of the hydrotrope dramatically increases the solubility of sparingly soluble organic molecules in water. Hydrotropic solutions precipitate the solute on dilution with water, which permits the recovery of the hydrotropic solution for re-use. Azides are the important intermediates in organic chemistry [8,

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jan 31, 2017

References

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