Res. Chem. Intermed.
, Vol. 34, Nos 5–7, pp. 475–486 (2008)
Koninklijke Brill NV, Leiden, 2008.
Also available online - www.brill.nl/rci
Hydrotalcite-bound ruthenium as a multifunctional
heterogeneous catalyst for one-pot synthesis of α-alkylated
nitriles and quinolines
, KOICHIRO JITSUKAWA
, KOHKI EBITANI
and KEN MOTOKURA
Department of Materials Engineering Science, Graduate School of Engineering Science,
Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan
Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of
Technology, Showa-ku, Nagoya 466-8555, Japan
Received 14 October 2006; accepted 4 January 2007
Abstract—This article reviews our recent progress in one-pot syntheses of α-alkylated nitriles and
quinolines by heterogeneous catalysis with hydrotalcite-bound ruthenium based on cooperative action
between cationic Ru species and the base sites of the hydrotalcite surface.
Keywords: One-pot synthesis; hydrotalcite-bound ruthenium; green chemistry.
One of the promising approaches to “green” and sustainable chemistry is to replace
conventional methods employing toxic and/or hazardous stoichiometric reagents
with atom-efﬁcient catalytic alternatives [1 –5]. In particular, heterogeneous cat-
alysts have the advantages of being operationally simple [6, 7] and enabling un-
precedented reactions based on speciﬁc surface ensemble sites within a regular
arrangement [8 –10]. We recently demonstrated a new strategy for designing high-
performance metal catalysts containing Pd, Cu, Sc, Ti, V and Fe by use of inorganic
materials as macroligands for catalytically active metal centers [11–18].
The design of multifunctional solid surfaces is one of the most important chal-
lenges in the creation of nanostructured heterogeneous catalysts which allow ad-
vanced versions of organic transformations. Herein, we focus on the preparation,
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