Russian Journal of Applied Chemistry, 2012, Vol. 85, No. 8, pp. 1239−1246.
Pleiades Publishing, Ltd., 2012.
Original Russian Text © O.V. Okatova, I.I. Gavrilova, N.N. Ul’yanova, E.F. Panarin, G.M. Pavlov, 2012, published in Zhurnal Prikladnoi Khimii, 2012,
Vol. 85, No. 8, pp. 1303−1310.
AND POLYMERIC MATERIALS
Hydrodynamic, Molecular, and Conformational Characteristics
of Macromolecules of a Random Copolymer
and N-Methyl-N-vinylamine Hydrochloride
O. V. Okatova, I. I. Gavrilova, N. N. Ul’yanova, E. F. Panarin, and G. M. Pavlov
Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg, Russia
Fock Research Institute of Physics, St. Petersburg State University, St. Petersburg, Russia
Received May 12, 2012
Abstract—The development and optimization of processes involving polymeric molecules require determination
and monitoring of key molecular characteristics of the polymer. Samples of poly-N-methyl-N-vinylacetamide were
synthesized and fractionated. Partial hydrolysis of the homopolymer fractions was performed, and fractions of
a random copolymer of N-methyl-N-vinylacetamide and N-methyl-N-vinylamine hydrochloride were obtained.
The molecular weights and conformational parameters of the homo- and copolymers in 0.2 M aqueous NaCl were
determined by methods of molecular hydrodynamics.
Owing to the development of commercial processes
for production of N-vinylamides (N-vinylacetamide,
N-vinyl-N-methylacetamide, N-vinylformamide, etc.)
and commercial availability of the monomers, the
interest in the polymers based on them sharply increased
. Poly-N-vinylamides and cationic polyelectrolytes
are actively used as ﬂ occulants for water treatment and
dehydration of residues  in paper production , in
biotechnology, and in cosmetics. Much interest in this
class of polymers is also due to their capability to inhibit
the formation of gas hydrates  arising in extraction
and processing of hydrocarbons. By partial hydrolysis of
poly-N-vinylamides, it is possible to control the charge of
a macromolecule, its hydrophobic–hydrophilic balance,
and thus its complexing and ﬂ occulating properties.
By now, the conformational and molecular
parameters of cyclic poly-N-vinylamides such as poly-
N-vinylpyrrolidone and poly-N-vinylcaprolactam
have been studied fairly well [5–7]. At the same time,
open-chain poly-N-vinylamides such as poly-N-
vinylformamide, poly-N-vinylacetamide, and poly-
N-methyl-N-vinylacetamide (PMVAA) have been
studied poorly . At the same time, these polymers
are of interest as being capable of polymer-analogous
transformations. N-Vinylamides and (co)polymers
based on them are of considerable interest as potential
carriers of biologically active substances.
In this study we prepared copolymers suitable for
the delivery of biologically active substances into living
bodies and examined the molecular characteristics of
these copolymers. The development and optimization of
processes based on the use of nanoobjects, polymeric
molecules, requires determination and control of the
most important molecular characteristics of polymers:
molecular weight, molecular-weight distribution,
copolymer composition, and, for polyelectrolytes, linear
charge density. In this connection, it is appropriate to
study the conformational and molecular characteristics