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Hydrocortisone overdose

Hydrocortisone overdose Reactions 1704, p187 - 2 Jun 2018 O S Iatrogenic Cushing’s syndrome secondary to compounding error: case report A 6-month-old-girl developed iatrogenic Cushing’s syndrome following an overdose of hydrocortisone secondary to compounding error [route not stated]. The girl, who had classic salt wasting congenital adrenal hyperplasia (CAH), was born with atypical genitalia. She was diagnosed with 21-hydroxylase deficiency. On day 2 of life, she started receiving hydrocortisone 2.5mg thrice daily, along with fludrocortisone and sodium chloride. The doses of fludrocortisone and hydrocortisone were decreased by six weeks of age. Hydrocortisone was prescribed at a dose of 5mg daily in three divided doses in the form of crushed weighed hydrocortisone tablets in capsules obtained from a local compounding pharmacy. During the first several months of th life, she had been tracking at the 90 percentile. However, she started developing growth deceleration at the age of six months. She had fallen to the first percentile of length by 16 months of age. Her weight was excessive at the st 91 percentile. On physical examination, she was found to have increased facial fat, excess body hair, plethora and irritability. Despite low dose hydrocortisone therapy 1mg thrice daily, her adrenal profile revealed persistent http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Hydrocortisone overdose

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018

Hydrocortisone overdose

Abstract

Reactions 1704, p187 - 2 Jun 2018 O S Iatrogenic Cushing’s syndrome secondary to compounding error: case report A 6-month-old-girl developed iatrogenic Cushing’s syndrome following an overdose of hydrocortisone secondary to compounding error [route not stated]. The girl, who had classic salt wasting congenital adrenal hyperplasia (CAH), was born with atypical genitalia. She was diagnosed with 21-hydroxylase deficiency. On day 2 of life, she started receiving hydrocortisone 2.5mg...
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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-018-46830-5
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p187 - 2 Jun 2018 O S Iatrogenic Cushing’s syndrome secondary to compounding error: case report A 6-month-old-girl developed iatrogenic Cushing’s syndrome following an overdose of hydrocortisone secondary to compounding error [route not stated]. The girl, who had classic salt wasting congenital adrenal hyperplasia (CAH), was born with atypical genitalia. She was diagnosed with 21-hydroxylase deficiency. On day 2 of life, she started receiving hydrocortisone 2.5mg thrice daily, along with fludrocortisone and sodium chloride. The doses of fludrocortisone and hydrocortisone were decreased by six weeks of age. Hydrocortisone was prescribed at a dose of 5mg daily in three divided doses in the form of crushed weighed hydrocortisone tablets in capsules obtained from a local compounding pharmacy. During the first several months of th life, she had been tracking at the 90 percentile. However, she started developing growth deceleration at the age of six months. She had fallen to the first percentile of length by 16 months of age. Her weight was excessive at the st 91 percentile. On physical examination, she was found to have increased facial fat, excess body hair, plethora and irritability. Despite low dose hydrocortisone therapy 1mg thrice daily, her adrenal profile revealed persistent

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References