Human Microsatellites: Mutation and Evolution

Human Microsatellites: Mutation and Evolution Microsatellites (MSs) are short tandem DNA repeats with the repetitive motif of two to six nucleotides, forming tracts up to hundreds of nucleotides long. Notwithstanding the active use of MSs in genetic studies of various biological problems, the reasons for their wide occurrence in the genome, their possible functions, and mutational behavior are still unclear. The mutation rate in MS repeats is on average several orders of magnitude higher than in the remaining DNA, which allows for direct estimation of evolutionary transformation rate in nucleotide sequences of the genome. Mutation process in MSs is highly heterogeneous, with distinct differences between species; furthermore, within a species it differs among loci with different repeat size, among alleles of one locus, and among individuals of different sex and age. Most MS mutations are caused by DNA slippage during replication but the probability of this event depends on the locus. In this review, a number of models of MS evolution are discussed, which account for the relationship between mutation rate and allele size, different mutation direction in alleles of different size, and the appearance of point mutations within repeat tracts restricting allele size. The MS evolution is considered mainly in the context of selective neutrality, although there is evidence showing functional significance of some variants of tandem repeats and thus their possible selective value. Russian Journal of Genetics Springer Journals

Human Microsatellites: Mutation and Evolution

Loading next page...
Kluwer Academic Publishers-Plenum Publishers
Copyright © 2004 by MAIK “Nauka/Interperiodica”
Biomedicine; Human Genetics
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial