Human herpesvirus 7 (HHV-7) is a lymphotropic virus which replicates in CD4+ T cells. The majority of DNA sequences of HHV-7, strain RK, were cloned, and the termini of the viral DNA inserts were sequenced. The clones were found to contain sequences homologous to HHV-6 DNA with the average relatedness amounting to 60% in the nucleotide sequence and 53.4% in the corresponding amino acid sequences. Human cytomegalovirus (HCMV) DNA was also found homologous but to a lower extent, while the human α and γ herpesviruses were more distinct. Some genes were found to be better conserved in all herpesviruses (core genes). These findings define the genetic makeup of HHV-7 DNA.
Archives of Virology – Springer Journals
Published: Feb 1, 1997
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