Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer_journal/human-embryonic-stem-cells-get-organized-hXw41n0pIU
References (10)
-
Ken Cho, B. Blumberg, H. Steinbeisser, E. Robertis (1991)
Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoidCell, 67
-
R. S. P. Beddington (1994)
Induction of a second neural axis by the mouse nodeDevelopment, 120
-
R. Beddington (1994)
Induction of a second neural axis by the mouse node.Development, 120 3
-
K. Gritsman (2000)
Nodal signaling patterns the organizerDevelopment, 127
-
I. Martyn, T. Kanno, A. Ruzo, E. Siggia, A. Brivanlou (2018)
Self-organization of a human organizer by combined WNT and NODAL signallingNature, 558
-
Kira Gritsman, W. Talbot, W. Talbot, A. Schier (2000)
Nodal signaling patterns the organizer.Development, 127 5
-
Aryeh Warmflash, B. Sorre, F. Etoc, E. Siggia, A. Brivanlou (2014)
A method to recapitulate early embryonic spatial patterning in human embryonic stem cellsNature methods, 11
-
H. Spemann, H. Mangold (1924)
Wilhelm Roux Arch. Entw. Mech. Org., 100
-
A. Arias, B. Steventon (2018)
On the nature and function of organizersDevelopment (Cambridge, England), 145
-
D. Crease, S. Dyson, J. Gurdon (1998)
Cooperation between the activin and Wnt pathways in the spatial control of organizer gene expression.Proceedings of the National Academy of Sciences of the United States of America, 95 8
- Publisher
- Springer Journals
- Copyright
- Copyright © Springer Nature Limited 2018
- Subject
- Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- DOI
- 10.1038/d41586-018-05115-y
- pmid
- 29872182
- Publisher site
- See Article on Publisher Site
Abstract
An embryo’s body plan is established by a structure called the organizer. Evidence of this structure in humans has been lacking, but a stem-cell-based protocol has now enabled researchers to demonstrate its existence.
Journal
Nature – Springer Journals
Published: Jun 7, 2018
Keywords: Biological techniques; Developmental biology; Stem cells