J Cancer Res Clin Oncol (2017) 143:1687–1699 DOI 10.1007/s00432-017-2417-3 ORIGINAL ARTICLE – CANCER RESEARCH Human circulating and tissue gastric cancer stem cells display distinct epithelial–mesenchymal features and behaviors 1 1 2 1 1 Shengliang Zhang · Yanna Shang · Tie Chen · Xin Zhou · Wengtong Meng · 3 1 1 1 1 Chuanwen Fan · Ran Lu · Qiaorong Huang · Xue Li · Xu Hong · 3 4 1 Zongguang Zhou · Jiankun Hu · Xianming Mo Received: 4 November 2016 / Accepted: 31 March 2017 / Published online: 20 April 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract human gastric adenocarcinoma. The CGCSCs and TGC- Introduction Metastasis is a leading cause of cancer- SCs were culture in a same serum free stem cell culture related-deaths worldwide. Recently, cancer stem cells medium, however the morphology are different with each (CSCs) have been believed to be responsible for tumor other. EMT-associated markers were measured by Immu- initiation and metastasis, but till now, difference of cellu- nofluorescence, Western Blotting, and RT-PCR methods, lar features and behaviors between CSCs from tumor tis- and the results indicated that the CGCSCs and TGCSCs sues (TCSCs) and circulation (CCSCs) remains largely carry different epithelial–mesenchymal
Journal of Cancer Research and Clinical Oncology – Springer Journals
Published: Apr 20, 2017
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