Human CD200 suppresses macrophage-mediated xenogeneic cytotoxicity and phagocytosis

Human CD200 suppresses macrophage-mediated xenogeneic cytotoxicity and phagocytosis Surg Today (2018) 48:119–126 https://doi.org/10.1007/s00595-017-1546-2 ORIGINAL ARTICLE Human CD200 suppresses macrophage‑mediated xenogeneic cytotoxicity and phagocytosis 1 1 1 1 1 Rieko Sakai · Akira Maeda · Thuy‑Vy Choi · Pei‑Chi Lo · Patmika Jiaravuthisan · 1 1 1 1 Afifah Mod Shabri · Han‑Tang Wang · Rei Matsuura · Tasuku Kodama · 1 1 1 Hiroshi Eguchi · Hiroomi Okuyama · Shuji Miyagawa Received: 14 February 2017 / Accepted: 22 May 2017 / Published online: 1 June 2017 © Springer Japan 2017 Abstract Conclusions Our findings indicate that human CD200 Purpose Various strategies, such as the generation of suppresses the xenogeneic rejection by CD200R mac- alpha-1,3-galactosyltransferase knocked-out pigs and rophages and that the generation of hCD200 transgenic CD55 transgenic pigs, have been investigated to inhibit pig pigs for use in xenografts is very attractive for preventing to human xenogeneic rejection. Our aim is to develop strat- the macrophage-mediated rejection. egies to overcome the hurdle of not only hyper acute rejec- tion, but also that of cellular xenogeneic rejection (CXR). Keywords CD200 · CD200R · Macrophage · Although macrophages have been well known to play a Xenotransplantation critical role in CXR, monocyte/macrophage-mediated xen- ogeneic rejection has not been well studied. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Surgery Today Springer Journals

Loading next page...
 
/lp/springer_journal/human-cd200-suppresses-macrophage-mediated-xenogeneic-cytotoxicity-and-3QEreZ9POC
Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer Japan
Subject
Medicine & Public Health; Surgery; Surgical Oncology
ISSN
0941-1291
eISSN
1436-2813
D.O.I.
10.1007/s00595-017-1546-2
Publisher site
See Article on Publisher Site

Abstract

Surg Today (2018) 48:119–126 https://doi.org/10.1007/s00595-017-1546-2 ORIGINAL ARTICLE Human CD200 suppresses macrophage‑mediated xenogeneic cytotoxicity and phagocytosis 1 1 1 1 1 Rieko Sakai · Akira Maeda · Thuy‑Vy Choi · Pei‑Chi Lo · Patmika Jiaravuthisan · 1 1 1 1 Afifah Mod Shabri · Han‑Tang Wang · Rei Matsuura · Tasuku Kodama · 1 1 1 Hiroshi Eguchi · Hiroomi Okuyama · Shuji Miyagawa Received: 14 February 2017 / Accepted: 22 May 2017 / Published online: 1 June 2017 © Springer Japan 2017 Abstract Conclusions Our findings indicate that human CD200 Purpose Various strategies, such as the generation of suppresses the xenogeneic rejection by CD200R mac- alpha-1,3-galactosyltransferase knocked-out pigs and rophages and that the generation of hCD200 transgenic CD55 transgenic pigs, have been investigated to inhibit pig pigs for use in xenografts is very attractive for preventing to human xenogeneic rejection. Our aim is to develop strat- the macrophage-mediated rejection. egies to overcome the hurdle of not only hyper acute rejec- tion, but also that of cellular xenogeneic rejection (CXR). Keywords CD200 · CD200R · Macrophage · Although macrophages have been well known to play a Xenotransplantation critical role in CXR, monocyte/macrophage-mediated xen- ogeneic rejection has not been well studied.

Journal

Surgery TodaySpringer Journals

Published: Jun 1, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off