Human CD200 suppresses macrophage-mediated xenogeneic cytotoxicity and phagocytosis

Human CD200 suppresses macrophage-mediated xenogeneic cytotoxicity and phagocytosis Surg Today (2018) 48:119–126 ORIGINAL ARTICLE Human CD200 suppresses macrophage‑mediated xenogeneic cytotoxicity and phagocytosis 1 1 1 1 1 Rieko Sakai · Akira Maeda · Thuy‑Vy Choi · Pei‑Chi Lo · Patmika Jiaravuthisan · 1 1 1 1 Afifah Mod Shabri · Han‑Tang Wang · Rei Matsuura · Tasuku Kodama · 1 1 1 Hiroshi Eguchi · Hiroomi Okuyama · Shuji Miyagawa Received: 14 February 2017 / Accepted: 22 May 2017 / Published online: 1 June 2017 © Springer Japan 2017 Abstract Conclusions Our findings indicate that human CD200 Purpose Various strategies, such as the generation of suppresses the xenogeneic rejection by CD200R mac- alpha-1,3-galactosyltransferase knocked-out pigs and rophages and that the generation of hCD200 transgenic CD55 transgenic pigs, have been investigated to inhibit pig pigs for use in xenografts is very attractive for preventing to human xenogeneic rejection. Our aim is to develop strat- the macrophage-mediated rejection. egies to overcome the hurdle of not only hyper acute rejec- tion, but also that of cellular xenogeneic rejection (CXR). Keywords CD200 · CD200R · Macrophage · Although macrophages have been well known to play a Xenotransplantation critical role in CXR, monocyte/macrophage-mediated xen- ogeneic rejection has not been well studied. Surgery Today Springer Journals

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Medicine & Public Health; Surgery; Surgical Oncology
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