Forschung aktuell Z Rheumatol 2018 · 77:409–411 J. Dong https://doi.org/10.1007/s00393-018-0485-7 Cell Biology, Deutsches Rheuma-Forschungszentrum Berlin, ein Institut der Leibniz Gemeinschaft, Berlin, Published online: 25 May 2018 Germany © Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2018 Redaktion Human bone marrow-resident A. Radbruch, Berlin R.E. Schmidt, Hannover R. Straub, Regensburg and blood-circulating memory U. Wagner, Leipzig T lymphocytes – + The paradigm that memory T lym- resident memory T (TRM) cells. TRM cells tomes of CD69 memory CD4 T cells of phocytes are continuously circulat- in epithelial barrier tissues can mediate blood and bone marrow are more similar, ing through the body in search of enhanced local eﬀector function, even in and distinct from that of CD69 memory their cognate antigen has recently the absence of neutralizing antibodies or T cells of bone marrow . A similarly been challenged by the discovery of circulating T cells from blood . Re- preserved core transcriptional signature memory T cells residing in a variety cently, wehaveshown that humanbone of human CD69 T cells has recently RM of tissues. In the past years we have marrow is a special compartment for the been deﬁned in lymphoid and mucosal established a line of
Zeitschrift für Rheumatologie – Springer Journals
Published: May 25, 2018
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