Human anelloviruses: an update of molecular, epidemiological and clinical aspects

Human anelloviruses: an update of molecular, epidemiological and clinical aspects Human torque teno viruses (TTVs) are new, emerging infectious agents, recently assigned to the family Anelloviridae. The first representative of the genus, torque teno virus (TTV), was discovered in 1997, followed by torque teno mini virus (TTMV) in 2000, and torque teno midi virus (TTMDV) in 2007. These viruses are characterized by an extremely high prevalence, with relatively uniform distribution worldwide and a high level of genomic heterogeneity, as well as an apparent pan-tropism at the host level. Although these viruses have a very high prevalence in the general population across the globe, neither their interaction with their hosts nor their direct involvement in the etiology of specific diseases are fully understood. Since their discovery, human anelloviruses, and especially TTV, have been suggested to be associated with various diseases, such as hepatitis, respiratory diseases, cancer, hematological and autoimmune disorders, with few arguments for their direct involvement. Recent studies have started to reveal interactions between TTVs and the host’s immune system, leading to new hypotheses for potential pathological mechanisms of these viruses. In this review article, we discuss the most important aspects and current status of human TTVs in order to guide future studies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Human anelloviruses: an update of molecular, epidemiological and clinical aspects

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Publisher
Springer Vienna
Copyright
Copyright © 2015 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-015-2363-9
Publisher site
See Article on Publisher Site

Abstract

Human torque teno viruses (TTVs) are new, emerging infectious agents, recently assigned to the family Anelloviridae. The first representative of the genus, torque teno virus (TTV), was discovered in 1997, followed by torque teno mini virus (TTMV) in 2000, and torque teno midi virus (TTMDV) in 2007. These viruses are characterized by an extremely high prevalence, with relatively uniform distribution worldwide and a high level of genomic heterogeneity, as well as an apparent pan-tropism at the host level. Although these viruses have a very high prevalence in the general population across the globe, neither their interaction with their hosts nor their direct involvement in the etiology of specific diseases are fully understood. Since their discovery, human anelloviruses, and especially TTV, have been suggested to be associated with various diseases, such as hepatitis, respiratory diseases, cancer, hematological and autoimmune disorders, with few arguments for their direct involvement. Recent studies have started to reveal interactions between TTVs and the host’s immune system, leading to new hypotheses for potential pathological mechanisms of these viruses. In this review article, we discuss the most important aspects and current status of human TTVs in order to guide future studies.

Journal

Archives of VirologySpringer Journals

Published: Apr 1, 2015

References

  • Emerging viral infections relevant to transfusion medicine
    Allain, JP
  • Mother-to-child transmission of TT virus: sequence analysis of non-coding region of TT virus in infected mother-infant pairs
    Bagaglio, S; Sitia, G; Prati, D; Cella, D; Hasson, H; Novati, R; Lazzarin, A; Morsica, G
  • Infection of TT virus in patients with idiopathic pulmonary fibrosis
    Bando, M; Ohno, S; Oshikawa, K; Takahashi, M; Okamoto, H; Sugiyama, Y
  • Human circoviruses
    Biagini, P
  • Prevalence and genotype distribution of TT virus in various specimen types from thalassaemic patients
    Chan, PK; Chik, KW; Li, CK; Tang, NL; Ming, MS; Cheung, JL; Ng, KC; Yuen, PM; Cheng, AF
  • TT-virus infection in North American blood donors, patients with fulminant hepatic failure, and cryptogenic cirrhosis
    Charlton, M; Adjei, P; Poterucha, J; Zein, N; Moore, B; Therneau, T; Krom, R; Wiesner, R
  • Hepatitis A virus in environmental water samples from the Amazon Basin
    Paula, VS; Diniz-Mendes, L; Villar, LM; Luz, SL; Silva, LA; Jesus, MS; Silva, NM; Gaspar, AM
  • Higher prevalence and viral load of TT virus in saliva than in the corresponding serum: another possible transmission route and replication site of TT virus
    Deng, X; Terunuma, H; Handema, R; Sakamoto, M; Kitamura, T; Ito, M; Akahane, Y
  • High prevalence of human Torque teno virus in streams crossing the city of Manaus, Brazilian Amazon
    Diniz-Mendes, L; Paula, VS; Luz, SL; Niel, C
  • Increased prevalence of transfusion-transmitted virus and cross-reactivity with immunodominant epitopes of the HRES-1/p28 endogenous retroviral autoantigen in patients with systemic lupus erythematosus
    Gergely, P; Pullmann, R; Stancato, C; Otvos, L; Koncz, A; Blazsek, A; Poor, G; Brown, KE; Phillips, PE; Perl, A
  • Possible pathogenic nature of the recently discovered TT virus: does it play a role in autoimmune rheumatic diseases?
    Gergely, P; Perl, A; Poor, G
  • Time to consider the concept of a commensal virus?
    Griffiths, P
  • One-year monthly monitoring of Torque teno virus (TTV) in wastewater treatment plants in Japan
    Haramoto, E; Katayama, H; Oguma, K; Yamashita, H; Nakajima, E; Ohgaki, S
  • Isolate KAV: a new genotype of the TT-virus family
    Heller, F; Zachoval, R; Koelzer, A; Nitschko, H; Froesner, GG
  • TTV, a new human virus with single stranded circular DNA genome
    Hino, S
  • Detection and viral nucleotide sequence analysis of transfusion-transmitted virus infection in acute fulminant and non-fulminant hepatitis
    Huang, YH; Wu, JC; Chiang, TY; Chan, YJ; Huo, TI; Huang, YS; Hwang, SJ; Chang, FY; Lee, SD

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