hrs gene and borders of compartments of imaginal wing disc in Drosophila melanogaster

hrs gene and borders of compartments of imaginal wing disc in Drosophila melanogaster Hepatocyte growth factor receptor tyrosine kinase substrate (hrs) is an endosome protein involved in the sorting and transport of receptor tyrosine kinases and other proteins (which are absorbed by the cell during endocytosis) from early endosomes to lysosomes. Since receptor tyrosine kinases are important components of different cellular signaling systems, hrs protein defects can result in the appearance of a number of developmental abnormalities. In particular, it was demonstrated that ectopic hrs expression in the wing disc results in the disappearance of one or several rows of marginal wing setae in imago (which indicates hrs gene involvement in the development of the disc D/V border). We previously confirmed hrs involvement in the developmental process of imaginal wing disc D/V border and demonstrated a change in the apterous gene expression pattern during ectopic hrs expression. The present report is devoted to the clarification and detailing of the hrs effect on D/V, as well as on A/P borders of the imaginal wing disc compartments in Drosophila melanogaster. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

hrs gene and borders of compartments of imaginal wing disc in Drosophila melanogaster

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Publisher
Springer Journals
Copyright
Copyright © 2015 by Pleiades Publishing, Inc.
Subject
Biomedicine; Human Genetics; Animal Genetics and Genomics; Microbial Genetics and Genomics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795415100117
Publisher site
See Article on Publisher Site

Abstract

Hepatocyte growth factor receptor tyrosine kinase substrate (hrs) is an endosome protein involved in the sorting and transport of receptor tyrosine kinases and other proteins (which are absorbed by the cell during endocytosis) from early endosomes to lysosomes. Since receptor tyrosine kinases are important components of different cellular signaling systems, hrs protein defects can result in the appearance of a number of developmental abnormalities. In particular, it was demonstrated that ectopic hrs expression in the wing disc results in the disappearance of one or several rows of marginal wing setae in imago (which indicates hrs gene involvement in the development of the disc D/V border). We previously confirmed hrs involvement in the developmental process of imaginal wing disc D/V border and demonstrated a change in the apterous gene expression pattern during ectopic hrs expression. The present report is devoted to the clarification and detailing of the hrs effect on D/V, as well as on A/P borders of the imaginal wing disc compartments in Drosophila melanogaster.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Oct 17, 2015

References

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