Host range conversion of murine leukemia virus resulting from recombination with endogenous virus

Host range conversion of murine leukemia virus resulting from recombination with endogenous virus Ecotropic murine leukemia viruses (MuLVs) are classified into B-, N-, or NB-tropic MuLV by their host range determined by the Fv-1 gene product. B-tropic MuLV is restricted in N-type mouse cells (Fv-1 n/n ) and N-tropic MuLV is restricted in B-type mouse cells (FV-1 b/b ). Although forced passages in a restrictive host grant a wider host range (NB-tropism), we show here a host range conversion from B to N tropism. The conversion was most likely a result of recombination between the exogenously infected B-tropic MuLV and an endogenously expressed N-tropic MuLV in a C57BL/6 mouse cell line, YH-7. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Host range conversion of murine leukemia virus resulting from recombination with endogenous virus

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Publisher
Springer-Verlag
Copyright
Copyright © Wien by 1997 Springer-Verlag/
Subject
Legacy
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s007050050064
Publisher site
See Article on Publisher Site

Abstract

Ecotropic murine leukemia viruses (MuLVs) are classified into B-, N-, or NB-tropic MuLV by their host range determined by the Fv-1 gene product. B-tropic MuLV is restricted in N-type mouse cells (Fv-1 n/n ) and N-tropic MuLV is restricted in B-type mouse cells (FV-1 b/b ). Although forced passages in a restrictive host grant a wider host range (NB-tropism), we show here a host range conversion from B to N tropism. The conversion was most likely a result of recombination between the exogenously infected B-tropic MuLV and an endogenously expressed N-tropic MuLV in a C57BL/6 mouse cell line, YH-7.

Journal

Archives of VirologySpringer Journals

Published: Jan 1, 1997

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