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- Publisher
- Springer Journals
- Copyright
- Copyright © 2017 by Springer Medizin Verlag GmbH
- Subject
- Medicine & Public Health; Gynecology; Obstetrics/Perinatology/Midwifery; Endocrinology
- ISSN
- 0017-5994
- eISSN
- 1433-0393
- DOI
- 10.1007/s00129-017-4095-2
- Publisher site
- See Article on Publisher Site
Abstract
Leitthema Gynäkologe 2017 · 50:606–611 T. Strowitzki DOI 10.1007/s00129-017-4095-2 Abt. für Gyn. Endokrinologie und Fertilitätsstörungen, Universitätsklinikum Heidelberg, Heidelberg, Online publiziert: 30. Juni 2017 Deutschland © Springer Medizin Verlag GmbH 2017 Redaktion O. Ortmann, Regensburg Hormonersatztherapie bei A. Schwenkhagen, Hamburg K. Schaudig, Hamburg prämaturer Ovarialinsuffizienz Rationale, Indikation und Dauer Prämature Ovarialinsuffizienz (POI) sche NICE(National Institute for Health Lebenserwartung bezeichnet die Einschränkung der Ovar- and Care Excellence)-Guideline „Meno- funktion mit einer Verringerung der pause: diagnosis and management“ [30] In einer holländischen Kohortenstudie Follikelreserve bzw. einem vorzeitigen und als eigenständig dieses Thema bear- mit 12.000 Frauen und einem Beobach- Funktionsverlust vor einem Lebensal- beitendeLeitliniedieLeitliniederESHRE tungszeitraum von 17 Jahren fand sich ter von 40 Jahren [11]. Dabei ist das (European Society of Human Reproduc- eine um 2 Jahre verkürzte Lebenserwar- POF(„premature ovarian failure“)-Syn- tion and Embryology) „Management of tung bei Frauen mit einem POF vor dem drom der Endpunkt mit einem völligen women with premature ovarian insuffi- 40. Lebensjahr [33]. Sistieren der ovariellen Aktivität. Die ciency“ [11]. Übergänge sind fließend und durchaus Verringerte Knochendichte und auch partiell reversibel [30]. Ursachen einer POI/eines POF erhöhtes Frakturrisiko DieUrsacheneinerPOIsindvielschichtig Im Vergleich zu Frauen mit regelrech- Für Frauen mit einer POI und können genetisch, autoimmun oder tem
Journal
Der Gynäkologe – Springer Journals
Published: Jun 30, 2017