J Cancer Res Clin Oncol (2017) 143:1771–1786 DOI 10.1007/s00432-017-2434-2 ORIGINAL ARTICLE – CANCER RESEARCH Homogeneous pancreatic cancer spheroids mimic growth pattern of circulating tumor cell clusters and macrometastases: displaying heterogeneity and crater-like structure on inner layer 1,2 1 1 2 1 Hao Feng · Bao-chi Ou · Jing-kun Zhao · Shuai Yin · Ai-guo Lu · 2,3 4 Eva Oechsle · Wolfgang E. Thasler Received: 26 September 2016 / Accepted: 21 April 2017 / Published online: 11 May 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract Results Single cells experienced different growth pat- Purpose Pancreatic cancer 3D in vitro models including terns to form SCTS, like signet ring-like cells, blastula-like multicellular tumor spheroid (MCTS), single cell-derived structures, and solid core spheroids. However, golf ball-like tumor spheroid (SCTS), tissue-derived tumor spheroid, and hollow spheroids could also be detected, especially when organotypic models provided powerful platforms to mimic DanG and Capan-1 cells were cultivated with fibroblast- in vivo tumor. Recent work supports that circulating tumor conditioned medium (p < 0.05). The size of golf ball-like cell (CTC) clusters are more efficient in metastasis seeding hollow spheroids hardly grew after getting matured. Only than single CTCs. The purpose of this study is to
Journal of Cancer Research and Clinical Oncology – Springer Journals
Published: May 11, 2017
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