HIV serology signal-to-cutoff ratio as a rapid method to predict confirmation of HIV infection

HIV serology signal-to-cutoff ratio as a rapid method to predict confirmation of HIV infection Early and rapid detection of patients with HIV is a key to preventing further transmission. The purpose of this study was to assess the ability of signal-to-cutoff (S/CO) ratio from initial screening fourth-generation HIV serology to predict subsequent confir- mation of HIV. Patients with a first-time positive HIV serology (S/CO ratio ≥ 1) from 2012 to 2016 were included. Ratios were compared to the results of confirmatory testing. Predictive probabilities (PPs) of a positive confirmatory result were calculated based on a logistic regression model. A total of 45,138 HIV serology tests were performed; 250 patients met inclusion criteria, comprising 84 (34%) HIV negative patients, 136 (54%) chronic infections, and 30 (12%) acute infections. The PP of a confirmed positive result increased with higher S/CO ratios, with a PP of 100% for a S/CO of 55 (95% CI 95–100). This study enables a more informed discussion of the probability of HIV infection, based on HIV serology S/CO thresholds, prior to a confirmatory result. . . . Keywords HIV serology Signal-to-cutoff ratio HIVinfection Acute HIV Introduction algorithms recommend a combination of immunoassays and molecular testing that may prolong turnaround times [3, 4]. Early and rapid detection of patients with HIV infection http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Clinical Microbiology Infectious Diseases Springer Journals

HIV serology signal-to-cutoff ratio as a rapid method to predict confirmation of HIV infection

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Biomedicine; Medical Microbiology; Internal Medicine
ISSN
0934-9723
eISSN
1435-4373
D.O.I.
10.1007/s10096-018-3290-y
Publisher site
See Article on Publisher Site

Abstract

Early and rapid detection of patients with HIV is a key to preventing further transmission. The purpose of this study was to assess the ability of signal-to-cutoff (S/CO) ratio from initial screening fourth-generation HIV serology to predict subsequent confir- mation of HIV. Patients with a first-time positive HIV serology (S/CO ratio ≥ 1) from 2012 to 2016 were included. Ratios were compared to the results of confirmatory testing. Predictive probabilities (PPs) of a positive confirmatory result were calculated based on a logistic regression model. A total of 45,138 HIV serology tests were performed; 250 patients met inclusion criteria, comprising 84 (34%) HIV negative patients, 136 (54%) chronic infections, and 30 (12%) acute infections. The PP of a confirmed positive result increased with higher S/CO ratios, with a PP of 100% for a S/CO of 55 (95% CI 95–100). This study enables a more informed discussion of the probability of HIV infection, based on HIV serology S/CO thresholds, prior to a confirmatory result. . . . Keywords HIV serology Signal-to-cutoff ratio HIVinfection Acute HIV Introduction algorithms recommend a combination of immunoassays and molecular testing that may prolong turnaround times [3, 4]. Early and rapid detection of patients with HIV infection

Journal

European Journal of Clinical Microbiology Infectious DiseasesSpringer Journals

Published: Jun 3, 2018

References

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