HIV Coreceptors

HIV Coreceptors J. Membrane Biol. 166, 75–90 (1998) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1998 Topical Review 1 1 2 2 D.S. Dimitrov , X. Xiao , D.J. Chabot , C.C. Broder Membrane Structure and Function Section, National Cancer Institute, FCRDC, Frederick, MD 21702, USA Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA Received: 31 October 1997/Revised: 1 June 1998 Introduction does not play a significant role in virus evolution and that viruses, especially retroviruses, could rapidly evolve to accommodate new receptors [102]. The evolution pro- Viruses have evolved to recognize a variety of cell sur- cess of some viruses, e.g., human immunodeficiency vi- face molecules and use them for delivering their ge- ruses (HIV), could involve the use of coreceptor mol- nomes into cells. We will use the term virus receptors ecules for gaining entry into the cell. Coreceptors should for those surface molecules in spite of the fact that they be distinguished from entry cofactors that may act at the did not originally develop to serve as receptors for vi- late stages of the entry process. We will further use the ruses, and in most cases do The Journal of Membrane Biology Springer Journals

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Copyright © Inc. by 1998 Springer-Verlag New York
Life Sciences; Biochemistry, general; Human Physiology
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