Russian Journal of Developmental Biolog3; Vol. 31, No. 2, 2000, pp. 124-130. Translated from Ontogenez, Vol. 31, No. 2, 2000, pp. 152-160. Original Russian Text Copyright 9 2000 by ZelenhL Zoshchuk. HISTORY OF SCIENCE History of Contemporary Chromosome Analysis: The Fundamental Contribution of Caspersson's Works A. V. Zelenin and N. V. Zoshchuk Engelhardt b~stitute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 117984 Russia; Fax: (7-095) 1351405; E-mail: azel@genome, eimb. relarn, ru Received April 28, 1999; in final form, September 30, 1999 Chromosome analysis based on the studies of indi- tures, including the chromosomes, and, most impor- vidual chromosomes is widely used in medical genet- tantly, the determination of the content of nucleic acids ics, selection, and molecular biology. The "Human and protein. Genome" program based on studies of individual chro- Using these devices, specifically a scanning cyto- mosomes is aimed at the complete sequencing of the photometer (Carlson et al., 1963), Caspersson started human genome. The nature of the differential stainabil- to study chemical heterogeneity along the metaphase ity of the chromosomes of different organisms (Rodi- chromosome. This study was based on a suggestion onov, 1999) and the identity or difference of individual that alkylating
Russian Journal of Developmental Biology – Springer Journals
Published: Nov 18, 2007
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