Historical perspectives on the biology of brain metastasis

Historical perspectives on the biology of brain metastasis Clin Exp Metastasis (2017) 34:365–367 DOI 10.1007/s10585-017-9859-5 COMMENTARY 1 2 3 J. Dawn Waters  · Reid Hoshide  · Rahul Jandial   Received: 24 July 2017 / Accepted: 1 September 2017 / Published online: 6 September 2017 © Springer Science+Business Media B.V. 2017 Curing cancer has been a national emphasis since Richard focus in the brain. Understanding the key and rate-limiting Nixon declared “war on cancer” upon signing the National steps of the process may reveal effective strategies to combat Cancer Act into law in 1971. Despite tremendous advances metastases. in prevention, diagnosis, and treatment, cancer remains the Once brain metastases are diagnosed, the survival rate at second most frequent cause of death in the United States 1-year is approximately 20% [2]. Beyond mortality, brain and a leading cause of death worldwide [1]. The most lethal metastases cause significant morbidity from headaches, event in the progression of this disease is the metastatic inva- seizures, neurologic deficits, and treatment side-effects. sion of cancer cells throughout the body, leading to 90% Standard practice often involves surgery, followed by radia- of cancer deaths [2]. Since cancers are often metastatic at tion therapy or radiosurgery to the brain. There is a limited the time of diagnosis, prevention and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical & Experimental Metastasis Springer Journals

Historical perspectives on the biology of brain metastasis

Loading next page...
Springer Netherlands
Copyright © 2017 by Springer Science+Business Media B.V.
Biomedicine; Cancer Research; Biomedicine, general; Oncology; Hematology; Surgical Oncology
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial