Historical perspectives on the biology of brain metastasis

Historical perspectives on the biology of brain metastasis Clin Exp Metastasis (2017) 34:365–367 DOI 10.1007/s10585-017-9859-5 COMMENTARY 1 2 3 J. Dawn Waters  · Reid Hoshide  · Rahul Jandial   Received: 24 July 2017 / Accepted: 1 September 2017 / Published online: 6 September 2017 © Springer Science+Business Media B.V. 2017 Curing cancer has been a national emphasis since Richard focus in the brain. Understanding the key and rate-limiting Nixon declared “war on cancer” upon signing the National steps of the process may reveal effective strategies to combat Cancer Act into law in 1971. Despite tremendous advances metastases. in prevention, diagnosis, and treatment, cancer remains the Once brain metastases are diagnosed, the survival rate at second most frequent cause of death in the United States 1-year is approximately 20% [2]. Beyond mortality, brain and a leading cause of death worldwide [1]. The most lethal metastases cause significant morbidity from headaches, event in the progression of this disease is the metastatic inva- seizures, neurologic deficits, and treatment side-effects. sion of cancer cells throughout the body, leading to 90% Standard practice often involves surgery, followed by radia- of cancer deaths [2]. Since cancers are often metastatic at tion therapy or radiosurgery to the brain. There is a limited the time of diagnosis, prevention and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical & Experimental Metastasis Springer Journals

Historical perspectives on the biology of brain metastasis

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Publisher
Springer Netherlands
Copyright
Copyright © 2017 by Springer Science+Business Media B.V.
Subject
Biomedicine; Cancer Research; Biomedicine, general; Oncology; Hematology; Surgical Oncology
ISSN
0262-0898
eISSN
1573-7276
D.O.I.
10.1007/s10585-017-9859-5
Publisher site
See Article on Publisher Site

Abstract

Clin Exp Metastasis (2017) 34:365–367 DOI 10.1007/s10585-017-9859-5 COMMENTARY 1 2 3 J. Dawn Waters  · Reid Hoshide  · Rahul Jandial   Received: 24 July 2017 / Accepted: 1 September 2017 / Published online: 6 September 2017 © Springer Science+Business Media B.V. 2017 Curing cancer has been a national emphasis since Richard focus in the brain. Understanding the key and rate-limiting Nixon declared “war on cancer” upon signing the National steps of the process may reveal effective strategies to combat Cancer Act into law in 1971. Despite tremendous advances metastases. in prevention, diagnosis, and treatment, cancer remains the Once brain metastases are diagnosed, the survival rate at second most frequent cause of death in the United States 1-year is approximately 20% [2]. Beyond mortality, brain and a leading cause of death worldwide [1]. The most lethal metastases cause significant morbidity from headaches, event in the progression of this disease is the metastatic inva- seizures, neurologic deficits, and treatment side-effects. sion of cancer cells throughout the body, leading to 90% Standard practice often involves surgery, followed by radia- of cancer deaths [2]. Since cancers are often metastatic at tion therapy or radiosurgery to the brain. There is a limited the time of diagnosis, prevention and

Journal

Clinical & Experimental MetastasisSpringer Journals

Published: Sep 6, 2017

References

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