Clin Exp Metastasis (2017) 34:365–367 DOI 10.1007/s10585-017-9859-5 COMMENTARY 1 2 3 J. Dawn Waters · Reid Hoshide · Rahul Jandial Received: 24 July 2017 / Accepted: 1 September 2017 / Published online: 6 September 2017 © Springer Science+Business Media B.V. 2017 Curing cancer has been a national emphasis since Richard focus in the brain. Understanding the key and rate-limiting Nixon declared “war on cancer” upon signing the National steps of the process may reveal effective strategies to combat Cancer Act into law in 1971. Despite tremendous advances metastases. in prevention, diagnosis, and treatment, cancer remains the Once brain metastases are diagnosed, the survival rate at second most frequent cause of death in the United States 1-year is approximately 20% . Beyond mortality, brain and a leading cause of death worldwide . The most lethal metastases cause significant morbidity from headaches, event in the progression of this disease is the metastatic inva- seizures, neurologic deficits, and treatment side-effects. sion of cancer cells throughout the body, leading to 90% Standard practice often involves surgery, followed by radia- of cancer deaths . Since cancers are often metastatic at tion therapy or radiosurgery to the brain. There is a limited the time of diagnosis, prevention and
Clinical & Experimental Metastasis – Springer Journals
Published: Sep 6, 2017
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