Historical injection solutions of quinine analyzed by HPLC/MS

Historical injection solutions of quinine analyzed by HPLC/MS Monatsh Chem (2017) 148:1613–1618 DOI 10.1007/s00706-017-1940-x ORIGINAL PAPER 1 1 2 1 3 • • • • Karel Kudla ´ c ˇek Karel Nesme ˇra ´ k Martin Stı ´cha Petr Kozlı ´k Jan Babica Received: 26 January 2017 / Accepted: 13 February 2017 / Published online: 30 June 2017 Springer-Verlag Wien 2017 Abstract Two injection solutions of quinine 79, 77 resp., Introduction years were analyzed using RP-HPLC. The conditions of separation were optimized. The quinine content is A study of historical pharmaceutical relicts is an interesting decreased about 13% for 79-year-old sample and about 8% part of archaeological chemistry [1, 2], as it helps reveal for 77-year-old sample, respectively. Quinotoxine has been the composition, purpose, and/or chemical changes of found as the decomposition product. The compounds were analyzed object in pharmaceutical as well as historical identified by MS , and the ESI fragmentation mechanisms context. Nevertheless, the analysis of mass produced of compounds found were proposed. medicinal products which are produced since the second Graphical abstract half of the 19th century are relatively rare yet. Only the following analyses have been published: a series of so- called patent medicines from the 19th century [3, 4], injection solution of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Monatshefte für Chemie - Chemical Monthly Springer Journals

Historical injection solutions of quinine analyzed by HPLC/MS

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Publisher
Springer Vienna
Copyright
Copyright © 2017 by Springer-Verlag Wien
Subject
Chemistry; Chemistry/Food Science, general; Organic Chemistry; Inorganic Chemistry; Analytical Chemistry; Physical Chemistry; Theoretical and Computational Chemistry
ISSN
0026-9247
eISSN
1434-4475
D.O.I.
10.1007/s00706-017-1940-x
Publisher site
See Article on Publisher Site

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