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PR Shiroma, YE Geda, DA Mrazek (2010)
Pharmacogenomic implications of variants of monoaminergic-related genes in geriatric psychiatryPharmacogenomics, 11
ND Volkow, GJ Wang, JS Fowler, J Logan, R Hitzemann, YS Ding, N Pappas, C Shea, K Piscani (1996)
Decreases in dopamine receptors but not in dopamine transporters in alcoholicsAlcohol Clin Exp Res, 20
E Dong, Y Chen, DP Gavin, DR Grayson, A Guidotti (2010)
Valproate induces DNA demethylation in nuclear extracts from adult mouse brainEpigenetics, 5
F Etchepare, E Pambrun, B Begaud, H Verdoux, M Tournier (2016)
Compliance of psychotropic drug prescription with clinical practice guidelines in older inpatientsFundamental & clinical pharmacology, 30
H Uchida, DC Mamo, BH Mulsant, BG Pollock, S Kapur (2009)
Increased antipsychotic sensitivity in elderly patients: evidence and mechanismsJ Clin Psychiatry, 70
JL Montalvo-Ortiz, J Keegan, C Gallardo, N Gerst, K Tetsuka, C Tucker, M Matsumoto, D Fang, JG Csernansky, H Dong (2014)
HDAC inhibitors restore the capacity of aged mice to respond to haloperidol through modulation of histone acetylationNeuropsychopharmacology, 39
O Agid, G Remington, S Kapur, T Arenovich, RB Zipursky (2007)
Early use of clozapine for poorly responding first-episode psychosisJ Clin Psychopharmacol, 27
K Ishibashi, K Ishii, K Oda, K Kawasaki, H Mizusawa, K Ishiwata (2009)
Regional analysis of age-related decline in dopamine transporters and dopamine D2-like receptors in human striatumSynapse, 63
TG Viana, AF Almeida-Santos, DC Aguiar, FA Moreira (2013)
Effects of aripiprazole, an atypical antipsychotic, on the motor alterations induced by acute ethanol administration in miceBasic Clin Pharmacol Toxicol, 112
S Peleg, F Sananbenesi, A Zovoilis, S Burkhardt, S Bahari-Javan, RC Agis-Balboa, P Cota, JL Wittnam, A Gogol-Doering, L Opitz, G Salinas-Riester, M Dettenhofer, H Kang, L Farinelli, W Chen, A Fischer (2010)
Altered histone acetylation is associated with age-dependent memory impairment in miceScience, 328
P Gareri, P De Fazio, VG Manfredi, G De Sarro (2014)
Use and safety of antipsychotics in behavioral disorders in elderly people with dementiaJ Clin Psychopharmacol, 34
P Gareri, C Segura-Garcia, VG Manfredi, A Bruni, P Ciambrone, G Cerminara, G De Sarro, P De Fazio (2014)
Use of atypical antipsychotics in the elderly: a clinical reviewClin Interv Aging, 9
S Lee, J Jeong, YU Park, Y Kwak, SA Lee, H Lee, H Son, SK Park (2012)
Valproate alters dopamine signaling in association with induction of Par-4 protein expressionPLoS One, 7
MV Simonini, LM Camargo, E Dong, E Maloku, M Veldic, E Costa, A Guidotti (2006)
The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylasesProc Natl Acad Sci U S A, 103
E Hoekzema, R Herance, S Rojas, D Pareto, S Abad, X Jimenez, FP Figueiras, F Popota, A Ruiz, E Torrent, FJ Fernandez-Soriano, M Rocha, M Rovira, VM Victor, JD Gispert (2010)
The effects of aging on dopaminergic neurotransmission: a microPET study of [11C]-raclopride binding in the aged rodent brainNeuroscience, 171
Q Li, H Xiao, K Isobe (2002)
Histone acetyltransferase activities of cAMP-regulated enhancer-binding protein and p300 in tissues of fetal, young, and old miceJ Gerontol A Biol Sci Med Sci, 57
P Gareri, P De Fazio, S De Fazio, N Marigliano, G Ferreri Ibbadu, G De Sarro (2006)
Adverse effects of atypical antipsychotics in the elderly: a reviewDrugs Aging, 23
JL Wiley, RL Evans (2008)
Evaluation of age and sex differences in locomotion and catalepsy during repeated administration of haloperidol and clozapine in adolescent and adult ratsPharmacological research: the official journal of the Italian Pharmacological Society, 58
M Suzuki, K Hatano, Y Sakiyama, Y Kawasumi, T Kato, K Ito (2001)
Age-related changes of dopamine D1-like and D2-like receptor binding in the F344/N rat striatum revealed by positron emission tomography and in vitro receptor autoradiographySynapse, 41
A Campbell, RJ Baldessarini, MC Cremens (1988)
Dose-catalepsy response to haloperidol in rat: effects of strain and sexNeuropharmacology, 27
HM Abdolmaleky, CL Smith, JR Zhou, S Thiagalingam (2008)
Epigenetic alterations of the dopaminergic system in major psychiatric disordersMethods Mol Biol, 448
HJ Heesbeen, S Mesman, JV Veenvliet, MP Smidt (2013)
Epigenetic mechanisms in the development and maintenance of dopaminergic neuronsDevelopment, 140
D Siuda, Z Wu, Y Chen, L Guo, M Linke, U Zechner, N Xia, G Reifenberg, H Kleinert, U Forstermann, H Li (2014)
Social isolation-induced epigenetic changes in midbrain of adult miceJournal of physiology and pharmacology : an official journal of the Polish Physiological Society, 65
D Willis-Martinez, HW Richards, NA Timchenko, EE Medrano (2010)
Role of HDAC1 in senescence, aging, and cancerExp Gerontol, 45
J Miyamoto, M Tsuji, H Takeda, M Ohzeki, H Nawa, T Matsumiya (2004)
Characterization of the anxiolytic-like effects of fluvoxamine, milnacipran and risperidone in mice using the conditioned fear stress paradigmEur J Pharmacol, 504
P Singh, MK Thakur (2014)
Reduced recognition memory is correlated with decrease in DNA methyltransferase1 and increase in histone deacetylase2 protein expression in old male miceBiogerontology, 15
A Graff-Guerrero, TK Rajji, BH Mulsant, S Nakajima, F Caravaggio, T Suzuki, H Uchida, P Gerretsen, W Mar, BG Pollock, DC Mamo (2015)
Evaluation of antipsychotic dose reduction in late-life schizophrenia: a prospective dopamine D2/3 receptor occupancy studyJAMA psychiatry, 72
A Fink-Jensen, LS Schmidt, D Dencker, C Schulein, J Wess, G Wortwein, DP Woldbye (2011)
Antipsychotic-induced catalepsy is attenuated in mice lacking the M4 muscarinic acetylcholine receptorEur J Pharmacol, 656
E Toussirot, W Abbas, KA Khan, M Tissot, A Jeudy, L Baud, E Bertolini, D Wendling, G Herbein (2013)
Imbalance between HAT and HDAC activities in the PBMCs of patients with ankylosing spondylitis or rheumatoid arthritis and influence of HDAC inhibitors on TNF alpha productionPLoS One, 8
L Greenbaum, B Lerer (2015)
Pharmacogenetics of antipsychotic-induced movement disorders as a resource for better understanding Parkinson’s disease modifier genesFront Neurol, 6
ND Volkow, RC Gur, GJ Wang, JS Fowler, PJ Moberg, YS Ding, R Hitzemann, G Smith, J Logan (1998)
Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individualsAm J Psychiatry, 155
M Markianos, J Hatzimanolis, L Lykouras (1999)
Dopamine receptor responsivity in schizophrenic patients before and after switch from haloperidol to risperidonePsychiatry Res, 89
V Kaasinen, N Kemppainen, K Nagren, H Helenius, T Kurki, JO Rinne (2002)
Age-related loss of extrastriatal dopamine D(2) -like receptors in womenJ Neurochem, 81
M Kozurkova, E Misurova, K Kropacova (1995)
Effect of aging and gamma radiation on acetylation of rat liver histonesMech Ageing Dev, 78
M Cazorla, FD Carvalho, MO Chohan, M Shegda, N Chuhma, S Rayport, SE Ahmari, H Moore, C Kellendonk (2014)
Dopamine D2 receptors regulate the anatomical and functional balance of basal ganglia circuitryNeuron, 81
L Tremolizzo, G Carboni, WB Ruzicka, CP Mitchell, I Sugaya, P Tueting, R Sharma, DR Grayson, E Costa, A Guidotti (2002)
An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerabilityProc Natl Acad Sci U S A, 99
H Uchida, DC Mamo (2009)
Dosing of antipsychotics in schizophrenia across the life-spectrumProg Neuro-Psychopharmacol Biol Psychiatry, 33
RA Bressan, K Erlandsson, HM Jones, RS Mulligan, PJ Ell, LS Pilowsky (2003)
Optimizing limbic selective D2/D3 receptor occupancy by risperidone: a [123I]-epidepride SPET studyJ Clin Psychopharmacol, 23
M Maleszewska, J Mawer, P Tessarz (2016)
Histone modification in aging and lifespan regulationCurr Mol Bio Rep, 2
DF Wong, D Young, PD Wilson, CC Meltzer, A Gjedde (1997)
Quantification of neuroreceptors in the living human brain: III. D2-like dopamine receptors: theory, validation, and changes during normal agingJ Cereb Blood Flow Metab, 17
Y Zeng, M Tan, J Kohyama, M Sneddon, JB Watson, YE Sun, CW Xie (2011)
Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in agingJ Neurosci, 31
ID Ionov, II Pushinskaya (2013)
Somatostatin antagonist induces catalepsy in the aged ratPsychopharmacology, 227
J Graff, LH Tsai (2013)
Histone acetylation: molecular mnemonics on the chromatinNat Rev Neurosci, 14
PS Chen, GS Peng, G Li, S Yang, X Wu, CC Wang, B Wilson, RB Lu, PW Gean, DM Chuang, JS Hong (2006)
Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytesMol Psychiatry, 11
V Kaasinen, H Vilkman, J Hietala, K Nagren, H Helenius, H Olsson, L Farde, J Rinne (2000)
Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brainNeurobiol Aging, 21
V Nieratschker, M Grosshans, J Frank, J Strohmaier, C Goltz, O El-Maarri, SH Witt, S Cichon, MM Nothen, F Kiefer, M Rietschel (2014)
Epigenetic alteration of the dopamine transporter gene in alcohol-dependent patients is associated with ageAddict Biol, 19
N Sen (2014)
Epigenetic regulation of memory by acetylation and methylation of chromatin: implications in neurological disorders, aging, and addictionNeuroMolecular Med, 29
KM Kirschbaum, C Hiemke, U Schmitt (2009)
Rotarod impairment: catalepsy-like screening test for antipsychotic side effectsThe International journal of neuroscience, 119
A Antonini, KL Leenders, H Reist, R Thomann, HF Beer, J Locher (1993)
Effect of age on D2 dopamine receptors in normal human brain measured by positron emission tomography and 11C-racloprideArch Neurol, 50
SK Kidd, JS Schneider (2010)
Protection of dopaminergic cells from MPP+-mediated toxicity by histone deacetylase inhibitionBrain Res, 1354
PE Lee, SS Gill, M Freedman, SE Bronskill, MP Hillmer, PA Rochon (2004)
Atypical antipsychotic drugs in the treatment of behavioural and psychological symptoms of dementia: systematic reviewBMJ, 329
JF Castellano, BR Fletcher, B Kelley-Bell, DH Kim, M Gallagher, PR Rapp (2012)
Age-related memory impairment is associated with disrupted multivariate epigenetic coordination in the hippocampusPLoS One, 7
DE Barnes, B Robinson, JG Csernansky, EP Bellows (1990)
Sensitization versus tolerance to haloperidol-induced catalepsy: multiple determinantsPharmacol Biochem Behav, 36
D Singh, J Hodgson (2010)
Neuroleptic sensitivity in the elderly: lesson from clinical practiceThe Australian and New Zealand journal of psychiatry, 44
P Aupperle (2006)
Management of aggression, agitation, and psychosis in dementia: focus on atypical antipsychoticsAmerican journal of Alzheimer’s disease and other dementias, 21
H Frieling, KD Romer, S Scholz, F Mittelbach, J Wilhelm, M De Zwaan, GE Jacoby, J Kornhuber, T Hillemacher, S Bleich (2010)
Epigenetic dysregulation of dopaminergic genes in eating disordersInt J Eat Disord, 43
M Dagnas, N Mons (2013)
Region- and age-specific patterns of histone acetylation related to spatial and cued learning in the water mazeHippocampus, 23
Z Vucetic, JL Carlin, K Totoki, TM Reyes (2012)
Epigenetic dysregulation of the dopamine system in diet-induced obesityJ Neurochem, 120
Y Aoyama, A Mouri, K Toriumi, T Koseki, S Narusawa, N Ikawa, T Mamiya, T Nagai, K Yamada, T Nabeshima (2014)
Clozapine ameliorates epigenetic and behavioral abnormalities induced by phencyclidine through activation of dopamine D1 receptorInt J Neuropsychopharmacol, 17
A Campbell, RJ Baldessarini (1981)
Effects of maturation and aging on behavioral response to haloperidol in the ratPsychopharmacology, 73
M Ren, Y Leng, M Jeong, PR Leeds, DM Chuang (2004)
Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein inductionJ Neurochem, 89
JO Rinne, J Hietala, U Ruotsalainen, E Sako, A Laihinen, K Nagren, P Lehikoinen, V Oikonen, E Syvalahti (1993)
Decrease in human striatal dopamine D2 receptor density with age: a PET study with [11C]racloprideJ Cereb Blood Flow Metab, 13
S Moriam, ME Sobhani (2013)
Epigenetic effect of chronic stress on dopamine signaling and depressionGenet Epigenet, 5
B Tang, B Dean, EA Thomas (2011)
Disease- and age-related changes in histone acetylation at gene promoters in psychiatric disordersTransl Psychiatry, 1
RA Sweet, BG Pollock (1998)
New atypical antipsychotics. Experience and utility in the elderlyDrugs Aging, 12
KA Neve, JK Seamans, H Trantham-Davidson (2004)
Dopamine receptor signalingJ Recept Signal Transduct Res, 24
Psychopharmacology (2017) 234:2385–2398 DOI 10.1007/s00213-017-4629-2 ORIGINAL INVESTIGATION Histone deacetylase inhibitors reverse age-related increases in side effects of haloperidol in mice 1 2 1 3 Janitza L. Montalvo-Ortiz & Daniel W. Fisher & Guadalupe Rodríguez & Deyu Fang & 1 1 John G. Csernansky & Hongxin Dong Received: 1 January 2017 /Accepted: 4 April 2017 /Published online: 18 April 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract specific lysine residues of H3 and H4 within the Drd2 pro- Background Older patients can be especially susceptible to moter in the striatum of aged mice. HDAC inhibitors, partic- antipsychotic-induced side effects, and the pharmacodynamic ularly VPA, restored striatal D2R protein levels and function- mechanism underlying this phenomenon remains unclear. We ality and reversed age- and drug-related histone modifications hypothesized that age-related epigenetic alterations lead to at the Drd2 promoter. decreased expression and functionality of the dopamine D2 Conclusions These results suggest that epigenetic changes at receptor (D2R), contributing to this susceptibility. the striatal Drd2 promoter drive age-related increases in anti- Methods In this study, we treated young (2–3 months old) and psychotic side effect susceptibility, and HDAC inhibitors may aged (22–24 months old) C57BL/6 mice with the D2R antag- be an effective adjunct treatment
Psychopharmacology – Springer Journals
Published: Apr 18, 2017
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