Histological analysis of capsule formation around silicone implants and comparison with titanium-coated silicone implants in rats

Histological analysis of capsule formation around silicone implants and comparison with... Silicone implants have been used for breast augmentation for more than 45 years. Complications, in particular capsular contracture, occur with an incidence of <10% and up to 60%. We investigated the influence of the surface of breast implants on the formation of capsular contracture by comparing silicone with titanium-coated silicone. Seventeen smooth saline-filled silicone (group A) and 14 saline-filled titanium-coated silicone (group B) implants were implanted in female Wistar rats. After 12 and 36 weeks, the implants and capsules were extracted; histological and immunohistochemical staining was performed. The evaluation of the capsules was performed by two examiners in a double-blinded manner. Histologically, no significant difference in total capsule thickness was found. There was a significant difference in synovial-like metaplasia layer (SLM) thickness between groups A and B ( p = 0.041). Regarding implantation time (12 vs. 36 weeks), a significant difference was found in SLM thickness ( p = 0.021). Immunohistochemical staining indicated a significantly lower infiltration with inflammatory cells in group B. A significant correlation ( p = 0.019) between a thick SLM layer and inflammatory cell infiltration was detected. Titanium-coated silicone implants reduce SLM thickness and capsular inflammatory cell infiltration. These findings postulate that titanium-coated silicone implants might point out a new chance in the prevention of capsular contracture. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Plastic Surgery Springer Journals

Histological analysis of capsule formation around silicone implants and comparison with titanium-coated silicone implants in rats

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Copyright © 2012 by Springer-Verlag
Medicine & Public Health; Plastic Surgery
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  • Histological analysis of silicone breast implant capsules and correlation with capsular contracture
    Siggelkow, W; Faridi, A; Spiritus, K; Klinge, U; Rath, W; Klosterhalfen, B
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