Histological analysis of anti-cancer drug loaded, targeted Mn:ZnS quantum dots in metastatic lesions of 4T1 challenged mice

Histological analysis of anti-cancer drug loaded, targeted Mn:ZnS quantum dots in metastatic... J Mater Sci: Mater Med (2017) 28:138 DOI 10.1007/s10856-017-5949-9 DELIVERY SYSTEMS Original Research Histological analysis of anti-cancer drug loaded, targeted Mn:ZnS quantum dots in metastatic lesions of 4T1 challenged mice 1,2 3 1,4 ● ● ● Ibrahim Birma Bwatanglang Faruq Mohammad Nor Azah Yusof 5 5,6 5 ● ● ● Nurul Elyani Mohammed Nadiah Abu Noorjahan Banu Alitheen 1 4 7 5 ● ● ● ● Jaafar Abdullah Mohd Zubir Hussein Yusuf Abba Noraini Nordin Nur Rizi Zamberi Received: 18 December 2016 / Accepted: 25 July 2017 © Springer Science+Business Media, LLC 2017 Abstract 5-Fluororaucil (5-FU) as anti-cancer drug was spleen and lungs. The 5-FU@FACS-Mn:ZnS composite reported to induce thymidine synthase (TS) overexpression induced anti-proliferative properties in these organs as and cancer cell resistance. To improve its therapeutic effi- compared to the free 5-FU drug. Unlike the 5-FU@FACS- cacy and selective targeting, here we developed a targeted Mn:ZnS treated groups which showed some specific mor- delivery system mediated by the active ligand-folate phological changes such as cell shrinkage without obvious receptor chemistry to deliver the 5-FU drug selectively presence of adipocytes, the excised section of the tumor in into the tumor microenvironment. The preparation was the untreated control group http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Materials Science: Materials in Medicine Springer Journals

Histological analysis of anti-cancer drug loaded, targeted Mn:ZnS quantum dots in metastatic lesions of 4T1 challenged mice

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Publisher
Springer US
Copyright
Copyright © 2017 by Springer Science+Business Media, LLC
Subject
Materials Science; Biomaterials; Biomedical Engineering; Regenerative Medicine/Tissue Engineering; Polymer Sciences; Ceramics, Glass, Composites, Natural Materials; Surfaces and Interfaces, Thin Films
ISSN
0957-4530
eISSN
1573-4838
D.O.I.
10.1007/s10856-017-5949-9
Publisher site
See Article on Publisher Site

Abstract

J Mater Sci: Mater Med (2017) 28:138 DOI 10.1007/s10856-017-5949-9 DELIVERY SYSTEMS Original Research Histological analysis of anti-cancer drug loaded, targeted Mn:ZnS quantum dots in metastatic lesions of 4T1 challenged mice 1,2 3 1,4 ● ● ● Ibrahim Birma Bwatanglang Faruq Mohammad Nor Azah Yusof 5 5,6 5 ● ● ● Nurul Elyani Mohammed Nadiah Abu Noorjahan Banu Alitheen 1 4 7 5 ● ● ● ● Jaafar Abdullah Mohd Zubir Hussein Yusuf Abba Noraini Nordin Nur Rizi Zamberi Received: 18 December 2016 / Accepted: 25 July 2017 © Springer Science+Business Media, LLC 2017 Abstract 5-Fluororaucil (5-FU) as anti-cancer drug was spleen and lungs. The 5-FU@FACS-Mn:ZnS composite reported to induce thymidine synthase (TS) overexpression induced anti-proliferative properties in these organs as and cancer cell resistance. To improve its therapeutic effi- compared to the free 5-FU drug. Unlike the 5-FU@FACS- cacy and selective targeting, here we developed a targeted Mn:ZnS treated groups which showed some specific mor- delivery system mediated by the active ligand-folate phological changes such as cell shrinkage without obvious receptor chemistry to deliver the 5-FU drug selectively presence of adipocytes, the excised section of the tumor in into the tumor microenvironment. The preparation was the untreated control group

Journal

Journal of Materials Science: Materials in MedicineSpringer Journals

Published: Aug 8, 2017

References

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