J Mater Sci: Mater Med (2017) 28:138 DOI 10.1007/s10856-017-5949-9 DELIVERY SYSTEMS Original Research Histological analysis of anti-cancer drug loaded, targeted Mn:ZnS quantum dots in metastatic lesions of 4T1 challenged mice 1,2 3 1,4 ● ● ● Ibrahim Birma Bwatanglang Faruq Mohammad Nor Azah Yusof 5 5,6 5 ● ● ● Nurul Elyani Mohammed Nadiah Abu Noorjahan Banu Alitheen 1 4 7 5 ● ● ● ● Jaafar Abdullah Mohd Zubir Hussein Yusuf Abba Noraini Nordin Nur Rizi Zamberi Received: 18 December 2016 / Accepted: 25 July 2017 © Springer Science+Business Media, LLC 2017 Abstract 5-Fluororaucil (5-FU) as anti-cancer drug was spleen and lungs. The 5-FU@FACS-Mn:ZnS composite reported to induce thymidine synthase (TS) overexpression induced anti-proliferative properties in these organs as and cancer cell resistance. To improve its therapeutic efﬁ- compared to the free 5-FU drug. Unlike the 5-FU@FACS- cacy and selective targeting, here we developed a targeted Mn:ZnS treated groups which showed some speciﬁc mor- delivery system mediated by the active ligand-folate phological changes such as cell shrinkage without obvious receptor chemistry to deliver the 5-FU drug selectively presence of adipocytes, the excised section of the tumor in into the tumor microenvironment. The preparation was the untreated control group
Journal of Materials Science: Materials in Medicine – Springer Journals
Published: Aug 8, 2017
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