Highly functionalized cyclic β-amino acid moieties as promising scaffolds in peptide research and drug design

Highly functionalized cyclic β-amino acid moieties as promising scaffolds in peptide research... Peptide-based drug research has received high attention in the field of medicinal chemistry over the past decade. For drug design, to improve proteolytic stability, it is desirable to include unnatural building blocks, such as conformationally restricted β-amino acid moieties, into the peptide sequence. Accordingly, the synthesis and incorporation of such conformationally rigid systems into novel type of peptides has gained large interest. Our research group has designed highly efficient methods for the construction of potential antimicrobial peptides. Moreover, a number of synthetic approaches have been developed for the synthesis of various pharmacologically interesting cyclic β-amino acid derivatives as monomers with multiple stereogenic centers. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Amino Acids Springer Journals

Highly functionalized cyclic β-amino acid moieties as promising scaffolds in peptide research and drug design

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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer-Verlag Wien
Subject
Life Sciences; Biochemistry, general; Analytical Chemistry; Biochemical Engineering; Life Sciences, general; Proteomics; Neurobiology
ISSN
0939-4451
eISSN
1438-2199
D.O.I.
10.1007/s00726-017-2439-9
Publisher site
See Article on Publisher Site

Abstract

Peptide-based drug research has received high attention in the field of medicinal chemistry over the past decade. For drug design, to improve proteolytic stability, it is desirable to include unnatural building blocks, such as conformationally restricted β-amino acid moieties, into the peptide sequence. Accordingly, the synthesis and incorporation of such conformationally rigid systems into novel type of peptides has gained large interest. Our research group has designed highly efficient methods for the construction of potential antimicrobial peptides. Moreover, a number of synthetic approaches have been developed for the synthesis of various pharmacologically interesting cyclic β-amino acid derivatives as monomers with multiple stereogenic centers.

Journal

Amino AcidsSpringer Journals

Published: May 30, 2017

References

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