Arch Toxicol (2017) 91:3207–3208 DOI 10.1007/s00204-017-2000-3 EDITORIAL Reham Hassan Received: 23 May 2017 / Accepted: 29 May 2017 / Published online: 12 June 2017 © Springer-Verlag Berlin Heidelberg 2017 Recently, Peter Jansen and colleagues have published a Recently, research on cholestatic liver disease has been comprehensive review article about the pathophysiology a particular focus in toxicological sciences (Miszczuk et al. of cholestatic liver disease (Jansen et al. 2017). One of the 2015; Deharde et al. 2016; Reif et al. 2015; Barosso et al. central key messages of this article is that cholestatic liver 2016; Crespo Yanguas et al. 2016) and imaging and image disease typically evolves with anatomically an ascend- analysis pipelines have been established to study mor- ing course, where the early lesions occur ‘downstream’ in phological and functional changes in liver disease (Ham- bile ducts, which later leads to ‘upstream’ bile salt medi- mad et al. 2014; Ghallab et al. 2016; Hoehme et al. 2010; ated damage of hepatocytes. An interesting lesson learned Drasdo et al. 2014; Godoy et al. 2013). Interestingly, drug from Jansen’s article is that three topological domains of induced liver injury (DILI) shows a different pathophysi- the biliary tree respond differently to cholestasis.
Archives of Toxicology – Springer Journals
Published: Jun 12, 2017
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