Annals of Hematology (2018) 97:1293–1294 https://doi.org/10.1007/s00277-018-3294-9 LETTER TO THE EDITOR Higher Sclerostin/SOST expression is associated with lower percentage of circulatory blasts and better prognosis in patients with myelofibrosis 1 2 2 3,4 1,5 1,2,5 Marko Lucijanic & Ana Livun & Katarina Marija Tupek & Tajana Stoos-Veic & Vlatko Pejsa & Rajko Kusec Received: 9 January 2018 /Accepted: 28 February 2018 /Published online: 12 March 2018 Springer-Verlag GmbH Germany, part of Springer Nature 2018 Dear Editor, of positive cells. SOST mRNA expression was normalized to Sclerostin (a product of SOST gene) acts as a main negative Abl and expressed as a ΔCT value. Correlations with clinical regulator of bone metabolism, exerting its properties through parameters were made. Optimal cut-off values for survival inhibition of canonical-WNT signaling-pathway (cWNT) in were determined using the ROC curve analysis. The Mann- osteoblasts . It is produced by osteocytes and bone marrow Whitney U test, the Spearman rank correlation, the Cox- (BM) cells. cWNT activation is implicated in pathogenesis of Mantel log rank test , and the Cox regression analysis were Philadelphia chromosome-negative myeloproliferative neo- used. Analyses were done using MedCalc Statistical Software plasms (Ph- MPNs) [2, 3], diseases characterized by remod- ver.18 (MedCalc Software
Annals of Hematology – Springer Journals
Published: Mar 12, 2018
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