Mammalian Genome 9, 843–845 (1998). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1998 High-resolution mapping of the truncate (tc) locus on mouse Chromosome 6 Maria N. Pavlova, Alicia M. Clark, Achim Gossler The Jackson Laboratory, Bar Harbor, Maine 04609, USA Received: 24 April 1998 / Accepted: 4 June 1998 The notochord plays a pivotal role in patterning axial mesodermal eny were generated by mating (tc/tc × CAST/Ei− +/+) F mice or structures and the central nervous system during embryogenesis. (tc/tc × MOLF/Ei− +/+) F mice with tc/tc mice. Since the pen- Defects in the notochord lead to malformations or agenesis of the etrance of the tc phenotype is incomplete on the CAST/Ei (46%) axial skeleton and of the spinal cord. Whereas the functions of the and MOLF/Ei (51%) genetic hybrid backgrounds used in these notochord are well established, little is known about the genetic backcrosses, only N mice with an unambiguous tc phenotype elements that control its development and integrity, and thus in- (absent or short tail) were analyzed. fluence pattern-forming processes. To understand the molecular The truncate mutation is located at map position 38 on mouse mechanisms underlying the temporal and spatial differences of Chr 6 (The
Mammalian Genome – Springer Journals
Published: Oct 1, 1998
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