Short Communications Incorporating Mouse Genome Mammalian Genome 10, 1098–1101 (1999). © Springer-Verlag New York Inc. 1999 High-resolution mapping of quantitative trait loci for emotionality in selected strains of mice 1 1 2 2 1 Maria Grazia Turri, Christopher J. Talbot, Richard A. Radcliffe, Jeanne M. Wehner, Jonathan Flint Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, UK Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA Received: 16 April 1999 / Accepted: 8 July 1999 While a genetic contribution to many behavioral traits is not in the result of the selection for high OFA scores, L1 and L2 selection doubt, attempts to find the genes themselves have not met with for low OFA scores, and C1 and C2 are derived from the control much success. One advance towards this goal has been the dem- lines. onstration that it is possible to map genes that determine variation The selection experiment demonstrated that open-field behav- in quantitatively measured behavioral traits with crosses between iors had a genetic basis and confirmed that there was a negative inbred strains (both rodents and insects have been used). Further genetic correlation between OFA and OFD. At some level, there- progress requires
Mammalian Genome – Springer Journals
Published: Nov 1, 1999
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