J Endocrinol Invest (2018) 41:395–402 https://doi.org/10.1007/s40618-017-0757-0 ORIGINAL ARTICLE High prevalence of papillary thyroid carcinoma in nodular Hashimoto’s thyroiditis at the first diagnosis and during the follow‑up 1,5 1 2,3 4 1,5 F. Boi · F. Pani · P. G. Calò · M. L. Lai · S. Mariotti Received: 19 April 2017 / Accepted: 26 August 2017 / Published online: 5 September 2017 © Italian Society of Endocrinology (SIE) 2017 Abstract 1.41–2.64, p < 0.0001], male sex (OR 3.44, CI 1.48–8.02, Background The association between Hashimoto’s thyroid- p = 0.004) and HT (OR 3.14; CI 1.08–9.31, p < 0.05). Malig- itis (HT) and papillary thyroid carcinoma (PTC) remains to nant histology (mostly PTC) was confirmed higher in HTN+ be elucidated. (48/70, 68.6%) compared to NG (15/37, 40.5%; p < 0.05). Materials and methods A total of 484 HT patients were Higher prevalence of extrathyroidal infiltration (24/48, 50%) retrospectively subdivided into two groups: 243 without and vascular invasion (25/48, 52%) was found in HTN+ vs thyroid nodules, TNs (HTN−) and 241 with TNs (HTN+). NG (2/15, 1.3% p < 0.01), (3/16, 1.8% p < 0.05), respectively. Fine-needle aspiration cytology was available in 152 HTN+ Conclusions This study confirms higher prevalence of sus - patients. This group was compared to a group of 161 patients picious/malignant cytology and PTC at histology in nodular with
Journal of Endocrinological Investigation – Springer Journals
Published: Sep 5, 2017
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