High opioids tolerance due to transmucosal fentanyl abuse

High opioids tolerance due to transmucosal fentanyl abuse Eur J Clin Pharmacol (2017) 73:1195–1196 DOI 10.1007/s00228-017-2272-9 LETTER TO THE EDITOR 1 1 1 1 Celine Eiden & Olivier Mathieu & Hélène Donnadieu-Rigole & Cécile Marrot & Hélène Peyrière Received: 8 March 2017 /Accepted: 23 May 2017 /Published online: 3 June 2017 Springer-Verlag Berlin Heidelberg 2017 Sir, before the withdrawal. During the hospitalization, methadone We would like to report a case of high opioids tolerance due to syrup 10 mg daily was introduced with titration. Methadone abuse of transmucosal fentanyl in a patient without history of interdoses were taken by the patient due to signs of opiate drug abuse. withdrawal. The withdrawal symptoms disappeared with a maintenance dosage of methadone of 20 mg/day. A 59-year-old man (75 kg) without history of drug abuse was admitted to the Emergency Department in May 2016 be- This case was notified to the regional addictovigilance cen- cause of a withdrawal syndrome (lacrimation, rhinorrhea, hot/ ter as recommended by the French health authorities [1]. At cold sensations, no muscular or articular pain). The patient the beginning of the hospitalization, toxicological urine drug explained that he attempted a self-withdrawal of his fentanyl screening by immune-enzymology assay was negative for consumption. He reported the use http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Clinical Pharmacology Springer Journals

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Springer Berlin Heidelberg
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Biomedicine; Pharmacology/Toxicology
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