Diabetologia (2017) 60:1791–1800 DOI 10.1007/s00125-017-4331-2 ARTICLE High glucose increases the formation and pro-oxidative activity of endothelial microparticles 1,2 1,2 1 1 Dylan Burger & Maddison Turner & Fengxia Xiao & Mercedes N. Munkonda & 1,2 1,2,3 Shareef Akbari & Kevin D. Burns Received: 14 February 2017 /Accepted: 18 May 2017 /Published online: 10 June 2017 Springer-Verlag GmbH Germany 2017 Abstract lation, reactive oxygen species (ROS) production and vessel Aims/hypothesis Individuals with diabetes exhibit increases in function were assessed. circulating endothelial microparticles (eMPs, also referred to Results Exposure of HUVECs to high glucose for 24 h caused as endothelial microvesicles), which are associated with endo- a threefold increase in eMP formation, increased mean particle thelial dysfunction and a heightened risk of cardiovascular size (269 ± 18 nm vs 226 ± 11 nm) and decreased surface NG LG HG complications. We have shown that eMPs are markers and charge. Compared with eMP or eMP ,eMP possessed mediators of vascular injury although their role in diabetes is approximately threefold greater pro-coagulant activity, stimu- unclear. We hypothesised that the composition and biological lated HUVEC ROS production to a greater extent (~250% of NG activity of eMPs are altered in response to high glucose
Diabetologia – Springer Journals
Published: Jun 10, 2017
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