Eur J Clin Pharmacol (2017) 73:1159–1164 DOI 10.1007/s00228-017-2275-6 PHARMACOEPIDEMIOLOGY AND PRESCRIPTION Hiccups in Parkinson’s disease: an analysis of cases reported in the European pharmacovigilance database and a review of the literature 1 2 3 2 2 U. Lertxundi & A.C Marquínez & S. Domingo-Echaburu & M.Á Solinís & B. Calvo & 2 4 4 2 A. Del Pozo-Rodríguez & M. García & C. Aguirre & A. Isla Received: 31 January 2017 /Accepted: 26 May 2017 /Published online: 9 June 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract disease, dopamine agonists, and hiccups, searching for specif- Background Some reports have suggested an association be- ic treatment recommendations for hiccups in this disease. tween dopamine agonists and hiccups, involuntary contrac- Results Both rotigotine and pramipexole fulfilled the criteria to tions that merit full clinical attention because they can be very generate a safety signal. We found 32 and 13 cases of hiccups debilitating. Many drugs frequently used to treat hiccups are associated with dopamine agonists in EudraVigilance and the formally contraindicated in Parkinson’s disease due to their literature, respectively. There were no specific recommenda- liability to worsen motor symptoms, making the treatment of tions for the management of hiccups in Parkinson’s disease in
European Journal of Clinical Pharmacology – Springer Journals
Published: Jun 9, 2017
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