Knowledge of genes responsible for aging and death is a prerequisite for determining the relative contributions of the different evolutionary factors responsible for the limited duration of life. Polymorphism of these genes probably accounts for the variation in lifespan. Previously, quantitative trait loci (QTLs) controlling this variation were mapped with the use of 98 recombinant inbred (RI) lines originating from two parental isogenicDrosophila melanogaster stocks. In each RI line, lifespan was measured for 25 males and 25 females, and alleles were established for 93 marker genes segregating between the parental lines. Significant correlation between marker segregation and lifespan was revealed for several chromosome regions. The lifespan genes had sex-specific effects and late age onset. In the present work, the effects of the QTLs were compared for homozygous and heterozygous flies. In Six out of the eight detected QTLs alleles that decreased lifespan were recessive. Heterosis was observed for a of QTL at 33E–38A. Thus, heterosis might contribute to maintaining variation in lifespan in natural populations.
Russian Journal of Genetics – Springer Journals
Published: Oct 13, 2004
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