Heteropolyacid supported on amine-functionalized halloysite nano clay as an efficient catalyst for the synthesis of pyrazolopyranopyrimidines via four-component domino reaction

Heteropolyacid supported on amine-functionalized halloysite nano clay as an efficient catalyst... An efficient heterogeneous hybrid catalyst was developed by functionalization of halloysite clay nanotubes by γ-aminopropyltriethoxysilane and then immobilization of a Keggin type heteropolyacid, phosphotungstic acid. This hybrid catalyst was characterized by SEM/EDX, FTIR and XRD and its catalytic activity for the synthesis of pyrazolopyranopyrimidine derivatives via four-component domino reaction of barbituric acid, hydrazine hydrate, ethyl acetoacetate and benzaldehyde was investigated. The results indicated that the hybrid system can promote the reaction to afford the desired products in high yields and short reaction times. The superior catalytic activity of this system was confirmed when compared with those reported, previously. Moreover, this novel heterogeneous catalyst was found to be easily separable and recyclable. It was re-used at least three times with negligible loss of activity. Significantly, this protocol can be extended to nonconventional green heating sources such as microwave and ultrasonic irradiations. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Heteropolyacid supported on amine-functionalized halloysite nano clay as an efficient catalyst for the synthesis of pyrazolopyranopyrimidines via four-component domino reaction

Loading next page...
 
/lp/springer_journal/heteropolyacid-supported-on-amine-functionalized-halloysite-nano-clay-KvY6XD5LpB
Publisher
Springer Netherlands
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2756-8
Publisher site
See Article on Publisher Site

Abstract

An efficient heterogeneous hybrid catalyst was developed by functionalization of halloysite clay nanotubes by γ-aminopropyltriethoxysilane and then immobilization of a Keggin type heteropolyacid, phosphotungstic acid. This hybrid catalyst was characterized by SEM/EDX, FTIR and XRD and its catalytic activity for the synthesis of pyrazolopyranopyrimidine derivatives via four-component domino reaction of barbituric acid, hydrazine hydrate, ethyl acetoacetate and benzaldehyde was investigated. The results indicated that the hybrid system can promote the reaction to afford the desired products in high yields and short reaction times. The superior catalytic activity of this system was confirmed when compared with those reported, previously. Moreover, this novel heterogeneous catalyst was found to be easily separable and recyclable. It was re-used at least three times with negligible loss of activity. Significantly, this protocol can be extended to nonconventional green heating sources such as microwave and ultrasonic irradiations.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Oct 8, 2016

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial