J Cancer Res Clin Oncol (2017) 143:1871–1878 DOI 10.1007/s00432-017-2437-z ORIGINAL ARTICLE – CLINICAL ONCOLOGY Heterogeneous oncologic outcomes according to surgical pathology in high‑risk prostate cancer: implications for better risk stratification and preoperative prediction of oncologic outcomes 1 2 3 4 Seung‑Kwon Choi · Myungsun Shim · Myong Kim · Myungchan Park · 3 3 5 3 Sangmi Lee · Cheryn Song · Hyung‑Lae Lee · Hanjong Ahn Received: 5 January 2017 / Accepted: 9 May 2017 / Published online: 18 May 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract 5-year biochemical recurrence-free survival rates of the Purpose To evaluate the better risk stratification based on patients in each group were 87.8, 64.6, and 41.4%, respec- surgical pathology, and to predict oncologic outcomes after tively. We developed a scoring system based on preopera- radical prostatectomy (RP) with a better scoring system in tive PSA, clinical stage, percentage of tumor positive core, high-risk prostate cancer (PCa) patients. and percentage of cores with a Gleason score 8–10. This Methods We evaluated high-risk PCa patients (PSA demonstrated internally and externally validated concord- >20 ng/ml, ≥cT3a, or Gleason score 8–10) who under- ance indices of 0.733 and 0.772, respectively. went RP between 2007 and 2013
Journal of Cancer Research and Clinical Oncology – Springer Journals
Published: May 18, 2017
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